• The functional analysis of this V fsX mutation is shown

  2019-05-22

  

  The functional analysis of this V1764fsX1786 mutation is shown in Fig. 3B; no current was observed, indicating severe loss-of-function. Although we did not investigate the mechanisms of this complete reduction in Na+ current in this mutation, Herfst et al [19]. reported a similar frameshift mutation

• MCL has a poor long term response to

  2019-05-22

  

  MCL has a poor long-term response to current treatment strategies, for the most commonly used R-CHOP chemotherapy (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisolone), the remission rate is good (75–96%) but brief in duration. Despite the study of several other chemotherapy regimens

• During a mean of months of follow up freedom

  2019-05-22

  

  During a mean of 41±29 months of follow-up, freedom from VT or VF was observed more frequently in the non-inducible group (24 of 30 (75%)) than in the inducible group (9 of 21 (43%), P=0.03). The estimated cumulative freedom from VT or VF was 88%, 83%, 75%, and 55% at the 1-, 2-, 3-, and 5-year foll

• Competing pressures for resources across sectors however

  2019-05-22

  

  Competing pressures for resources across sectors, however, mean that increasing the proportion of resources for health will be difficult. Efficiency gains in the health sector could help to make the case for more investment. Countries need to tackle major sources of inefficiency by doing more of the

• Despite impressive progress towards elimination

  2019-05-21

  

  Despite impressive progress towards elimination, social unrest, gaps in the coverage of populations at risk, competing health interests, and possible donor fatigue present challenges to successful elimination of human African trypanosomiasis caused by and subsequent maintenance of this status. The

• Esta postura foi decisiva para

  2019-05-21

  

  Esta postura foi decisiva para as alianças confeccionadas pelas lideranças políticas e/ou religiosas (neo) pentecostais nas eleições seguintes. O apoio a Collor em 1989 e a Fernando Henrique Cardoso em 1994 teve como objetivo a oposição ao candidato Lula, do Partido dos Trabalhadores (pt), à Presidê

• Permanent pacemaker implantation with trans IVC access was f

  2019-05-21

  

  Permanent pacemaker implantation with trans-IVC access was first reported in 23 cases by Ellestad et al., in 1980 [2]; it was then reported in 95 cases, of which the early cases were published in 1989 by the same author as the largest series reported thus far [5]. Mathur et al. also reported 27 case

• Introduction Neuroblastoma NB which arises

  2019-05-21

  

  Introduction Neuroblastoma (NB), which arises from embryonal neural crest cells, is the most common extra-cranial solid tumor of childhood and accounts for more than 15% of all child cancer death [1,2]. Patients with NB frequently manifest disseminated disease at first visit and prognosis of these

• Phosphorus is essential for organic activity such as cellula

  2019-05-21

  

  Phosphorus is essential for organic activity such as cellular signal transduction, membrane transport, mineral metabolism, and tryptophan hydroxylase exchange [1]. Bone and teeth store 80% of the total body phosphorus. Intracellular phosphorus consists of the form of organic compounds such as adeno

• Hay que remontar a la

  2019-05-21

  

  Hay que remontar fluvastatin la Guerra Civil española que movilizó a los poetas hispanoamericanos de una manera mucho más urgente que la Segunda Guerra Mundial, para hallar el origen de los lazos de Octavio Paz con Chile. En 1937 Octavio Paz recibió una invitación para participar en el Congreso Inte

• The very fact that providing a greater number of doses

  2019-05-21

  

  The very fact that providing a greater number of doses of IPTp-SP is incrementally effective, even in settings where the parasite is sensitive, also highlights the potential benefit of interventions using more effective drugs. This finding means there is either scope to improve clearance of existing

• br Does ambulatory monitoring prevent HF decompensation

  2019-05-20

  

  Does ambulatory monitoring prevent HF decompensation? While vigilant monitoring of symptoms and signs (and BNP levels) is useful, it does not guarantee the accurate prediction of ADHF. On the other hand, frequent monitoring of some of these signs and symptoms and the use of external physiological

• br Discussion Zoledronic acid has been approved for preventi

  2019-05-20

  

  Discussion Zoledronic MLN4924 manufacturer has been approved for prevention and treatment of osteoporosis and glucocorticoids-induced osteoporosis, treatment of Paget\'s disease, hypercalcemia, multiple myeloma and bone metastasis. In the particular case of breast cancer, it is recommended as a

• Efforts to estimate the global burden

  2019-05-20

  

  Efforts to estimate the global burden of typhoid fever can be traced to a meeting of the Pan American Health Organization in 1984 and publication of the outcome in 1986. Although an important first step, the 1984 study was recognised as having a number of limitations including provision of scanty me

• The very fact that providing a

  2019-05-20

  

  The very fact that providing a greater number of doses of IPTp-SP is incrementally effective, even in settings where the parasite is sensitive, also highlights the potential benefit of interventions using more effective drugs. This finding means there is either scope to improve clearance of existin

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