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br Acknowledgments This work was supported by grants from
2019-06-17
Acknowledgments This work was supported by grants from the National Science Council (project number: MOST-103-2320-B-040-004 and NSC 102-2313-B-002 -039 -MY3). The authors would like to thank Dr. Bernard A. Schwetz for carefully reading the manuscript and helpful discussions which improved the a
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Implementation of contemporary treatment protocols incorpora
2019-06-17
Implementation of contemporary treatment protocols, incorporating adjuvant chemotherapy, have resulted in an improvement in the prognosis of patients diagnosed with osteosarcoma over the past decades. The overall 5-year survival rate has improved from less than 20% in the 1960s to approximately 60%
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br Material and methods br Results br Discussion PV
2019-06-17
Material and methods Results Discussion PV isolation is currently the cornerstone for treatment of patients with paroxysmal AF [6]. An extended technique is circumferential PV isolation using point-by-point ablation around the PV ostium. However, that is a technically challenging and time-c
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IBA An ERP in the ECG has been shown to
2019-06-17
An ERP in the ECG has been shown to be familial [187–189]. ERP and ERS have been associated with variants in 7 genes. Consistent with the findings that IK-ATP activation can generate an ERP in canine ventricular wedge preparations, variants in KCNJ8 and ABCC9, responsible for the pore- forming and A
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br In mid close to the finish line
2019-06-15
In mid-2015, close to the finish line of the Millennium Development Goals (MDGs), Tanzania has reason to be proud. As Hoviyeh Afnan-Holmes and colleagues note in their Countdown to 2015 case study, Tanzania is on track to achieve MDG4: a two-thirds ambroxol hydrochloride in child mortality. The la
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No conviene ignorar la enorme
2019-06-15
No conviene ignorar la enorme influencia cultural de Estados Unidos en la formación intelectual de Vasconcelos, so pena de caer en contradicciones. Ulises criollo se asienta en una tradición muy estadounidense, la de una fascinación por las cuestiones de la individualidad, la identidad y la autobiog
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br Ocular surface squamous neoplasia OSSN has emerged as
2019-06-15
Ocular surface squamous neoplasia (OSSN) has emerged as an important manifestation of the HIV epidemic, especially in sub-Saharan Africa. This region has not only gained the unenviable position of having the highest prevalence of OSSN, but patients with HIV tend to present with larger tumours and
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Notwithstanding issues of equity improvement of research cap
2019-06-15
Notwithstanding issues of equity, improvement of research capacity in LMICs has practical benefits. People working and living in LMICs are better placed to define issues of importance to their populations than are people living thousands of miles away in HICs—who often fund research based on their o
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br Treatment and follow up recommendations
2019-06-15
Treatment and follow-up recommendations for patients receiving aromatase inhibitors Conclusions and future directions It is evident that, in addition to BMD, clinical risk factors can greatly influence fracture risk. In addition to morbidity and mortality, fractures are associated with high he
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In silico prediction software SIFT PolyPhen CADD and other p
2019-06-15
In silico prediction software, SIFT [51], PolyPhen2 [52], CADD [53], and other prediction systems are useful to evaluate a specific mutation which is detected in a patient. However, even if the in silico software predicts a mutation as pathogenic, we need to examine whether the genetic result is com
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br Interpretation of identified genetic variants
2019-06-15
Interpretation of identified genetic variants and genetic counseling Although the current expert consensus statement recommends that comprehensive or BrS1 (SCN5A) targeted BrS genetic testing can be useful for genetic testing [63], not all the published SCN5A mutations in BrS have been subjected
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br Conflict of Interest br Acknowledgments br Introduction
2019-06-15
Conflict of Interest Acknowledgments Introduction Human ether-a-go-go-related gene (hERG) encodes the alpha subunit of the rapidly-activating delayed-rectifier K+ channel, which plays a pivotal role in repolarization of cardiac action potentials (APs) [1]. Most of mutant hERG proteins causi
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En este proceso de integraci n
2019-06-15
En este proceso de integración y unidad latinoamericana y caribeña, la imagen política y diplomática de Estados Unidos se vio seriamente mermada por su terrible campaña contra el terrorismo. Su economía se mantiene sumergida en una aguda crisis financiera desde 2008, la más profunda desde 1929. A pe
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Los dedos son las cuatro mil verdades
2019-06-14
Los dedos son las cuatro mil verdades vistas por los ojos de las moscas. La labor del escritor, entonces, se pone Wortmannin la altura de la labor del detective: encontrar los diez dedos, descubrir el cuerpo flotando en el agua, dar con una cabeza que yace en el fondo de un río y nombrarla por su no
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br Discussion Primary lymphoma of
2019-06-14
Discussion Primary lymphoma of bone is a rare disease, first described by Oberling in 1928 and he labeled it as reticulum cell sarcoma of bone because of the presence of characteristic reticulin fibers within the lesion [5]. This work was followed by Parker and Jackson and later by Ivin and Bosto
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