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Large yellow croaker Larimichthys crocea are
2019-07-02
Large yellow croaker (Larimichthys crocea) are widely cultured in China but have inferior meat texture compared with wild fish. This result results from excess lipid deposition in the muscle, which reduces mechanical strength (Thakur et al., 2003). The liver is the central of lipid metabolism and st
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AMPK is a master regulator of metabolic
2019-07-02
AMPK is a master regulator of metabolic homeostasis, its broad spectrum of metabolic activities makes it an attractive target for treatment of metabolic and related disorders including Diabetes and Obesity (Madhavi et al., 2018). It controls lipid metabolism through its target genes PPAR-γ, C/EBP-α
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br Conclusions br Acknowledgements This
2019-07-02
Conclusions Acknowledgements This work was supported by funding from the Natural Sciences and Engineering Research Council of Canada (RGPIN-2017-06346 to JB), National Institute of Child Health and Human Development (5R01HD083930-02 to JB), and the National Institute of Biomedical Imaging and
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Introduction Breast cancer is a highly prevalent malignancy
2019-07-02
Introduction Breast cancer is a highly prevalent malignancy. There are some recognized risk factors for breast cancer, like early menarche or late menopause, which increase the length of the exposure to hormones, as a result of a higher number of ovarian cycles [1]. Moreover, there is evidence supp
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EphB promotes tumor growth by stimulating angiogenesis
2019-07-02
EphB4 promotes tumor growth by stimulating angiogenesis through EphrinB2 [18]. However, the distinct and specifically involvement of AZD-9291 weight and veins in the tumor angiogenesis of all tumor grades is unclear. Our results indicate that the relation between EphrinB2 and EphB4 stained blood ve
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br Conclusion Our study demonstrates that the effects of Epa
2019-07-02
Conclusion Our study demonstrates that the effects of Epac activation are strongly conditioned by the steady-state Ca levels at which the myocyte is functioning. As intracellular Ca increases, the activity of CaMKII enhances and the phosphorylation of its SR substrates acquires different relevanc
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Methods br Results First we
2019-07-02
Methods Results First, we compared Aβ plaque number, Aβ concentration, and neurobehavior functions between naive APP/PS1 and APP/PS1xEP1−/− mice. Significantly lower Aβ burden in APP/PS1xEP1−/− mice was evidenced by fewer plaques in the hippocampal area and a lower concentration of soluble Aβ42
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In a study on the time course of a mechanism
2019-07-01
In a study on the time course of a mechanism-based inactivation of CYP3A by HIV protease inhibitors, Katzenmaier et al. [37] reported that the suppression of CYP3A activity continued for threedays after the discontinuation of ritonavir. In the present study, the CYP3A activity on day 28 after a seve
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In present study we measured
2019-07-01
In present study, we measured the methylation and INF39 levels of CDKL2 in HCC tissues and cell lines. Meanwhile, correlations between the methylation and mRNA expression, clinicopathological features were evaluated. Materials and methods Results Discussion DNA methylation is a heritable
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9-Phenanthrol T helper Th cells play a central role
2019-07-01
T helper (Th) 9-Phenanthrol play a central role in activation of immune system against infectious agents through secretion of lymphokines or cytokines. African trypanosomes target the Th cells and alter their activation, possibly for their own survival and perpetuity (Namangala, 2011). Trypanosoma
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br Materials and methods br Results br Discussion Human
2019-07-01
Materials and methods Results Discussion Human Chk, a member of the Csk-family, was initially cloned from two different megakaryocytic cell lines [2], [3]. Structural comparison of human Chk with human Csk shows that human Chk has the additional N-terminal unique domain [2], [3], [25]. Chk
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br In a Comment February we argued that action
2019-07-01
In a Comment (February, 2017), we argued that action on the conditions currently referred to as non-communicable diseases (NCDs) may be hampered by the inadequacy of their label. We received a remarkable amount of feedback on this suggestion, and in this Comment we synthesise the responses garnere
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br In a detailed analysis using multiple data
2019-07-01
In a detailed analysis using multiple data sources in this issue of , Emily Keats and colleagues show that Kenya made some progress in reducing maternal and newborn mortality between 2003 and 2015, and made greater progress in reducing child mortality between 1998 and 2015, after earlier increases
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After permanent pacemaker implantation the lead electrocardi
2019-07-01
After permanent pacemaker implantation, the 12-lead electrocardiogram revealed that the pacing spike appeared at the same time as the P wave and narrow QRS complexes with AV conduction (Fig. 4). This finding demonstrated effective enforcement of the left atrial pacing. The patient had no postoperati
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The associated cardiovascular diagnoses were hypertension in
2019-07-01
The associated cardiovascular diagnoses were hypertension in 59.1% of the patients, coronary artery disease in 10.1%, cardiomyopathy in 8.3%, valvular Moniliformin sodium salt disease in 13.7%, and artificial cardiac valves in 3.1%. Thus, hypertension was the most common underlying disease in patie
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