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It should be noted that not only glyphosate but E
2019-07-04
It should be noted that not only glyphosate but E2 at the same concentration range (10−11-10−7 M) also showed similar effects on the expression of the po1 molecular regulating proteins. Furthermore, we could not see a significant difference among this concentration range of glyphosate and E2 on oth
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br Introduction Receptor tyrosine kinases RTKs are criticall
2019-07-04
Introduction Receptor tyrosine kinases (RTKs) are critically involved in the development and progression of human cancers and are therefore useful targets for anti-cancer therapies [1]. The Eph receptors represent the largest subfamily of receptor protein kinases and interact with ligands called
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br Materials and methods br Results br Discussion DAS and
2019-07-04
Materials and methods Results Discussion DAS and nilotinib, as the second potent, oral generation TKIs, bind to both the active and inactive conformation of the ABL1 kinase domain, have been found to be effective in treating patients with IM resistant or intolerant CML-CP, and inhibit all t
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Our results indicate an OT
2019-07-04
Our results indicate an OT-specific activation of PKR that inactivates eIF2a and may, by this means, reduce protein translation by utilizing only select sensors and mediators of the UPR (i.e., avoiding significant PERK activation). Interferon is a PKR activator [32] that temporarily subdues cellular
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AG-221 In attempts to further purify His Artemis numerous
2019-07-04
In attempts to further purify [His]6-Artemis, numerous matrices were assessed including anion and cation exchange, and AG-221 interaction chromatography. The results from these matrices were universally poor (data not shown). Fractionation via adsorption chromatography on a hydroxyapatite (HAP) mat
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Because of the complexity of DNA damage
2019-07-04
Because of the complexity of DNA damage and its repair, several pathways are candidates in HN2-induced DPC repair. Considering the 23kDa molecular weight of MGMT, NER may be ineffective for MGMT-adduct removal. This presumption is supported by that the mRNA level of ERCC1, a core gene in NER pathwa
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To compare glucose metabolism via oxidative phosphorylation
2019-07-04
To compare glucose metabolism via oxidative phosphorylation to that via glycolysis, a bioenergetics plot was constructed (Fig. 3A). In most cells, a decrease in one bioenergetics pathway is compensated by an increase in the other. However, following NAT1 deletion, there was a decrease in both oxidat
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The new ESC guidelines incorporate data from a
2019-07-04
The new ESC guidelines incorporate data from a network meta-analysis of 100 studies confirming that new-generation drug-eluting stents (DES) improve survival compared with medical treatment, although this has not been demonstrated in any individual study. REVASCULARIZATION IN NON–ST-ELEVATION ACU
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Additionally both in vitro and in vivo studies showed that
2019-07-04
Additionally, both in vitro and in vivo studies showed that a Ca2+ influx is closely related to apoptosis (Rizzuto et al., 2003). Calmodulin (CaM) is a multifunctional intermediate calcium-binding messenger protein expressed in all eukaryotic cells, which senses intracellular calcium levels by bind
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br Substrate Specificity Discrimination and Binding Energy I
2019-07-04
Substrate Specificity, Discrimination, and Binding Energy In Sitagliptin phosphate to catalytic efficiency, which can be gauged in reference to an absolute scale of ‘catalytic perfection’ 10, 11, specificity is a relative concept because it requires comparison between given alternative substrate
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Early diagnosis of CVS and
2019-07-04
Early diagnosis of CVS and DCI is a key issue in the management of SAH patients. In this regard, CT Perfusion (CTP) is the most accurate and sensitive method for noninvasive imaging assessment of cerebral ischemia with a great value for prediction and early diagnosis of CVS and DCI. CTP is a relativ
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The biological actions of ET are mediated
2019-07-04
The biological actions of ET‐1 are mediated via two distinct receptor subtypes, the endothelin A and endothelin B receptors (ETA/ETB). While activation of ETA is assumed to mediate contraction of smooth muscle cells, the activity of ETB is related to transient vasodilation [22]. In human corpus cave
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On the other hand the IL promoter activity induced
2019-07-04
On the other hand, the IL-8 promoter activity induced by the signalling cascade of the CysLT1-G300S receptor is higher than that of the WT receptor. The chemokine IL-8 is mainly involved in the recruitment and activation of neutrophils and we have previously shown that this chemokine gene is a targe
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br Materials and methods br Results br Discussion
2019-07-04
Materials and methods Results Discussion In the present study, as a trial to evaluate the marine ciliate E. crassus for further studies, its susceptibilities to B[a]P and β-NF were measured. Acute toxicity of B[a]P in aquatic organisms has been extensively studied, but not enough data is av
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The early serologic response of infants to infection with
2019-07-04
The early serologic response of infants to infection with HIV-1 is obscured by the presence of transplacentally acquired maternal HIV antibody. However, the HIV Phosphatase Inhibitor Cocktail 1 (100X in DMSO) produced in vitro by peripheral blood from infants has been studied (Pollack et al., 1993)
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