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Some mechanistic experiments performed in the early s by Ong
2019-07-27
Some mechanistic experiments performed in the early 2000s by Ongusaha et al. [78], suggest that DDR1 induction protects Ferrostatin-1 is from apoptosis in a p53-dependent manner, and that impairment of DDR1 expression or function leads to a pronounced increase of DNA damage-induced apoptosis. This
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br Introduction Sphingolipids are ubiquitous membrane compon
2019-07-27
Introduction Sphingolipids are ubiquitous membrane components of all eukaryotic cells belonging to a group of complex lipids. The basic structure of sphingolipids is composed of a sphingoid long chain base (LCB) linked to a fatty BMS 193885 via an amide bond to form a ceramide [1]. In animals, s
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ApicomplexansApicomplexans are unicellular and spore forming
2019-07-26
ApicomplexansApicomplexans are unicellular and spore-forming obligate intracellular parasites that occupy diverse host niches (Mogi and Kita 2010). They have remodeled mitochondrial carbon and energy metabolism through reductive evolution. The development of novel drugs is now a very serious challen
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br Materials and methods br
2019-07-26
Materials and methods Results Discussion To our knowledge, this is the first large-scale longitudinal measurement of more than 20 cytokines in normal pregnancy. Simultaneous measurements of several cytokines with multiplex magnetic bead-based immunoassays are becoming increasingly common in
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BAY85-3934 br Introduction Sphingolipids are ubiquitous
2019-07-26
Introduction Sphingolipids are ubiquitous membrane components of all eukaryotic cells belonging to a group of complex lipids. The basic structure of sphingolipids is composed of a sphingoid long chain base (LCB) linked to a fatty BAY85-3934 via an amide bond to form a ceramide [1]. In animals, sp
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Similarly LTD concentration dependently enhanced AQP express
2019-07-26
Similarly, LTD4 concentration-dependently enhanced AQP4 expression in astrocytes (Fig. 3). The LTD4-enhanced AQP4 expression was not affected by pranlukast but inhibited by Bay u9773, a non-selective CysLT1/CysLT2 receptor antagonist [33]. Because no selective CysLT2 receptor antagonists are current
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br Introduction Alzheimer s disease AD
2019-07-26
Introduction Alzheimer’s disease (AD) is the progressive version of mild cognitive impairment and usually met by the elderly population. It falls into the class of neurodegenerative disorders that attacks the SAR 405 to nerves cells, or neurons, resulting in loss of memory, impairment of thinkin
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Introduction It has been well stablished the role
2019-07-26
Introduction It has been well stablished the role of CRF in somatic pain regulation (Yarushkina et al., 2011, Yarushkina et al., 2016). However, the effects of CRF in pain relief are controversial and it has been described anti- and pronociceptive effects (Ji et al., 1995, Larauche et al., 2009, N
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Another question concerns the mechanism
2019-07-26
Another question concerns the mechanism of PC reduction during the phosphate starvation response. There are at least three main mechanisms of PC depletion: suppression of PC synthesis due to substrate exhaustion, downregulation of PC synthase expression by suppression of gene transcription or intens
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Our primary research question is that of
2019-07-26
Our primary research question is that of the comparative efficacy of accelerated and traditional accounting programs as manifest by success on the CPA exam. We recognize that due to a number of personal and career decisions, not all of those qualified from any of our programs will attempt the CPA ex
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Introduction Safety critical systems are defined
2019-07-26
Introduction Safety-critical systems are defined as those systems where failure could result in the loss of life or injury to people, damage to equipment or to the environment [9]. Safety standards, e.g., [41], [17], [18], [6], [38], expect appropriate safety analysis tasks to be integrated within
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melk inhibitor The present study manipulated dopaminergic fu
2019-07-26
The present study “manipulated” dopaminergic functioning by examining genetic variation related to the catechol-O-methyltransferase (COMT) gene. The gene transcribes the COMT enzyme involved in degradation of released dopamine in the frontal cortex. COMT is primarily localized to the frontal cortex
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Animal studies investigating the role of
2019-07-26
Animal studies investigating the role of D1 dopamine receptors in the PFC have focused on delayed response tasks, which require online maintenance of a previously presented stimulus. Striatal dopamine is thought to be important for flexibility and updating goal representations when new information i
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SEA0400 to In cholesterol synthesis HMG CoA reductase
2019-07-26
In cholesterol synthesis, HMG-CoA reductase is the rate limiting step in cholesterol biosynthesis. Statins or HMG-CoA reductase inhibitors are commonly used for management of hypercholesterolemia. The presence of an HMG-like moiety on these drugs allows them to competitively bind to the catalytic d
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An ideal CHK inhibitor would be minimally cytotoxic while
2019-07-26
An ideal CHK-1 inhibitor would be minimally cytotoxic, while enhancing the anti-tumor effect of a real cytotoxic agent that would be used in combination with the inhibitor. Our CHK-1 inhibitors have shown excellent selectivity over a panel of kinases including those regulating the cell cycle, but th
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