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Neuroinflammation is the one of the emerging causal factors
2019-08-21
Neuroinflammation is the one of the emerging causal factors contributing to these cognitive deficits. Therefore, we further tested the hypothesis that neuroinflammation is a key component contributing to the progression of spatial memory deficits during HH. Spatial memory deficits were observed afte
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Notochord is a transient structure differentiating
2019-08-21
Notochord is a transient structure differentiating at early stage during embryogenesis that is at the origin of vertebral bodies in all vertebrates. In zebrafish, it is composed of vacuolated gabazine to surrounded by a unique ECM structure improperly called notochordal BM. As in chicken and amphibi
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RCT pathway plays a critical role in the maintenance
2019-08-21
RCT pathway plays a critical role in the maintenance of cholesterol homeostasis by facilitating the cholesterol clearance and cholesterol efflux (Levinson & Wagner, 2015). In the process of RCT, ABCA1 and ABCG1 played as crucial regulators in cholesterol efflux (Yasuda et al., 2011). Compared with h
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br Materials and methods br Results and discussion br Conclu
2019-08-21
Materials and methods Results and discussion Conclusions Acknowledgments This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government (MEST) (No. 2011-0030635) and the MarineBio Research Program (NRF-C1ABA001-2011-0018561). The Fonta
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Estrogen treatment in postmenopausal women requires combinat
2019-08-21
Estrogen treatment in postmenopausal women requires combination with a progestogen in order to prevent endometrial stimulation. This is not necessary, however, with tibolone as progestogenic activity is associated with its Δ4-metabolite that is formed in the liver, as well as locally in the endometr
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Our recent QTL mapping study revealed that the adaptor genes
2019-08-21
Our recent QTL mapping study revealed that the adaptor genes, including the NCK genes and the ABI genes, are located within the genomic regions harboring the most significant QTL (Zhou et al., 2017), suggesting that these genes could be involved in the determination of resistance, and possibly throu
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Since ET was discovered first and showed
2019-08-21
Since ET-1 was discovered first and showed a wide variety of actions not only on the cardiovascular system but also on various other tissues, much information has accumulated on ET-1 compared with the two other peptides. The method for measurement of ET-1 levels in plasma or various tissues by means
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The attachment of ubiquitin to RTKs such as
2019-08-21
The attachment of ubiquitin to RTKs, such as EGFR, mediates efficient delivery through the endosome-lysosome system for proteolysis. In this way, RTK degradation enables cessation of signal transduction. A recent siRNA screen identified a number of USPs that can significantly modulate EGFR levels an
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One of the most fundamental distinctions
2019-08-21
One of the most fundamental distinctions between Ub signals is substrate monoubiquitination versus polyubiquitination. With the exception of the E2, UBE2W, which represents a special case because it MS023 powder only ubiquitinates the flexible N-termini of substrates [5], [6], [20], most examples o
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The preferences for source of FAs for
2019-08-21
The preferences for source of FAs for DGAT1 and DGAT2 are related to their membrane topologies, subcellular locations, interactions with other proteins or organelles (discussed in the former section), and their differential expression, substrate specificities, and enzyme kinetics. According to UniPr
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br Subjects and methods br Results br Discussion In
2019-08-20
Subjects and methods Results Discussion In the present study, we found significantly increased CSF levels of IL-4, IL-5, IL-9, IL-10, TNF-α, CXCL8/IL-8, and VEGF-A together with significantly higher detection rates of IL-6, GM-CSF, PDGF-BB and IL-1ra in IHP patients compared with OND patien
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Annexin V-Biotin Apoptosis Kit To determine the time course
2019-08-20
To determine the time course of ZD2767P+CPG2 DNA–DNA interstrand cross-link formation, HT29 and LS174T colorectal tumour Annexin V-Biotin Apoptosis Kit were exposed to the drug for 10, 30 or 60 min. The levels of DNA interstrand cross-links in HT29 or LS174T cells did not increase with exposure ti
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Results from H also complement work of
2019-08-20
Results from H5 also complement work of the AICPA Board of Examiners, which has concluded “newly licensed CPAs must demonstrate higher-order skills such as critical thinking, problem solving, analytical ability, and skepticism more frequently. It is critically important that newly licensed CPAs are
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Therefore the SPH algorithm in AUTODYN D was used to
2019-08-20
Therefore, the SPH algorithm in AUTODYN-3D™ was used to simulate the experiment in Ref. [5] to verify the credibility of the numerical simulation method by results that could be measured accurately. Then the verified numerical simulation method was used to simulate BAD generated by RHA subjected to
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CM AVM and VOGM are thought to be
2019-08-20
CM-AVM and VOGM are thought to be two distinct disorders, with CM-AVM characterized by atypical CMs, with or without AVM in variable body parts, while VOGM is a type of cerebral AVM [16]. The fact that VOGM is infrequently reported as the AVM in CM-AVM patients, and CMs are quite often identified in
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