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rucaparib The absorption rate of polyphenols into the body i
2019-09-02
The rucaparib rate of polyphenols into the body is usually low. For example, the absorption rate of epigallocatechin gallate (EGCG), an active component in GP, is approximately 1% (Chen et al., 1997). To increase absorption of GP in the body, people have been increasing their intake of functional fo
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This research was funded by grants from the
2019-09-02
This research was funded by grants from the National Institute on Aging (2R01AG017141-06A2) and the National Center for Complementary and Alternative Medicine (P01AT002034). We also acknowledge the facilities service core of the Environmental Health Science Center (NIEHS ES00240). The authors would
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br Acknowledgements This work was
2019-08-30
Acknowledgements This work was financially supported by Industrial Technology Institute, Sri Lanka through funds received from Sri Lankan Government Treasury (TG13/69). G. D. Liyanaarachchi received postgraduate research scholarship grant from National Science Foundation Sri Lanka (NSF/SCH/2017/0
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train ride The enantiomeric ratio ER of chiral compounds acc
2019-08-30
The enantiomeric ratio (ER) of chiral compounds accumulated in organisms has been found to be different among species (Borga and Bidleman, 2005, Harner et al., 1999, Warner et al., 2005, Wiberg et al., 2000), indicating enantioselective accumulation of chiral compounds are species-specific. The ER o
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Our results implicate a critical role for CXCR
2019-08-30
Our results implicate a critical role for CXCR-1 in promoting the migration of colonic tumor cells. Expression of this receptor, but not CXCR-2, increased significantly because of the EMT (Fig. 3). Moreover, although Clone A enolase express comparable levels of both IL-8 receptors, only CXCR-1 inhi
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Mild cognitive impairment MCI is a clinical transitional
2019-08-30
Mild cognitive impairment (MCI) is a clinical transitional stage between normal aging and Alzheimer disease (AD) [1]. Approximate 15–30% MCI patients convert to AD annually. Although many efforts have been taken to prevent the conversion from MCI to AD [2], [3], there are few biomarkers to predict t
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It has only recently been appreciated that
2019-08-30
It has only recently been appreciated that antigen-activated LB Broth, Miller undertake two additional transient migrations during the early stages of T-dependent antibody responses. In the first of these, antigen-activated B cells migrate rapidly (within 2–3h) to the outer regions of the follicle
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br DGAT protein interactions Although DGAT and DGAT are
2019-08-30
DGAT-protein interactions Although DGAT1 and DGAT2 are membrane proteins of the ER, the ER contains within its extensive three-dimensional network different, unique structural and functional protein domains that arise from the non-uniformity imposed on it by the intracellular structures it intera
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At ngL DEX did not affect our investigated parameters
2019-08-30
At 3000ngL−1, DEX did not affect our investigated parameters, suggesting that DEX is regulated by CYP450 in a biphasic way, a response to xenobiotics that is not uncommon (Heinrichs et al., 1994). These data might also suggest that fish adapted to DEX exposure. It was previously shown that, dependin
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Several studies on the collagen receptor DDR have
2019-08-29
Several studies on the collagen receptor DDR1 have revealed a defined collagen signaling pathway that causes cell scattering and cadherin switching. As mentioned earlier, DDR BIIB021 on collagens are distinct from integrin binding sites; therefore, the same collagen protein can bind to DDR and inte
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N acetylation by N acetyltransferase
2019-08-29
N-acetylation by N-acetyltransferase (NAT) is an important metabolic pathway for some substances, and there are 2 functional NAT isoforms in humans—NAT1 and NAT2. Studies of etamicastat in healthy subjects showed an extensive N-acetylation of etamicastat to the inactive metabolite BIA 5-961, and a l
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br Biological roles of DGK br Summary and
2019-08-29
Biological roles of DGKϵ Summary and future perspectives The most ceramide segment of DGKϵ, comprised of residues 20–42, appears to have no role in binding the lipid substrate DAG or in the acyl chain specificity of substrate phosphorylation. Nevertheless, the sequence in this segment of DGKϵ
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The fibrillogenesis process of collagen is understood to ini
2019-08-29
The fibrillogenesis process of collagen is understood to initiate in the extracellular space near the plasma membrane where secretory vesicles form regions of deep invagination. However, it is not clear how and when collagen-binding proteins interact with collagen molecules during fibrillogenesis or
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E cadherin is an adhesive Ca dependent transmembrane protein
2019-08-29
E-cadherin is an adhesive Ca2+ dependent transmembrane protein mediating tight and strong cell-cell adhesion through homophilic interactions. There is strong evidence in favour of the major role of E-cadherin in melanocytes adhesion to keratinocytes in the BIRB 796 (Tang et al., 1994). The expressio
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After repeated intermittent exposure to a psychostimulant an
2019-08-29
After repeated, intermittent exposure to a psychostimulant an augmentation of drug response to motor activity is commonly observed, a phenomenon known as behavioral sensitization (Kalivas and Stewart, 1991, Steketee and Kalivas, 2011). On the other hand, several reports have pointed out that stress
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