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br Acknowledgement Work in the
2024-04-24
Acknowledgement Work in the McEwan Laboratory is funded by the Chief Scientist Office of Scottish Government: Grants ETM-258 and ETM-382. BE is supported by an Erasmus scholarship (D -JENA01). Introduction The equine placenta is a noninvasive transient organ, classified as diffuse and epithel
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Similarly results obtained in our lab using experimental dia
2024-04-24
Similarly, results obtained in our lab using experimental diabetic encephalopathy induced by streptozotocin (STZ) in C57BL-6 mice showed that the hippocampus of the diabetic animals exhibited reactive gliosis, neuronal loss, NF-kB signaling activation as well as high levels of IL-1β and vascular end
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Perhaps the first evidence of
2024-04-24
Perhaps the first evidence of AMPKs therapeutic ability in DM1 came from Thomas Cooper’s laboratory where they demonstrated that insulin-independent glucose uptake was unaffected in human DM1 muscle Chaetocin treated with MET, an AMPK activator and first-line therapy for type 2 diabetes mellitus [7
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br Conclusions Extract of non
2024-04-24
Conclusions Extract of non-germinated winter rape seeds cv. Bellevue was screened for the aminopeptidase activity. It revealed broad substrate specificity, with the highest activity toward Phe-pNA. Also in the partially purified sample, phenylalanine was preferentially hydrolysed. PMSF, known ser
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br Methods br Results br Discussion Agitation in
2024-04-24
Methods Results Discussion Agitation in dementia has recently been defined as a syndrome characterized by inferred or observed evidence of emotional distress associated with at least one behavioral component, i.e. excessive motor activity, verbal or physical aggression (Cummings et al., 201
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Heart failure is a chronic syndrome in which the
2024-04-24
Heart failure is a chronic syndrome in which the heart is unable of pumping an adequate supply of blood to meet the metabolic requirements of the body or generating the required elevated ventricular filling pressures to maintain output [34]. Despite considerable advances in the treatment of heart fa
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Fmoc-Ala-OMe Furthermore stress hormones can indirectly
2024-04-24
Furthermore, stress hormones can indirectly induce DNA damage, for example by altering DNA repair and transcriptional regulation of the cell cycle. It has been found that stress hormones induce the up-regulation of checkpoint kinase 1 (Chk1) and checkpoint kinase 2 (Chk2) and proto-oncogene cell div
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Mt a known to be upregulated
2024-04-24
Mt2a, known to be upregulated by ozone (Inoue et al., 2008), was also increased in vehicle-pretreated rats exposed to ozone, however, this effect was markedly reduced by both PROP and MIFE, suggesting that the neuroendocrine response is linked to ozone-induced acute phase protein expression. In huma
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In the presence of detrimental
2024-04-24
In the presence of detrimental conditions, such as inflammation, hypoxia, ischemia trauma or neoplastic milieu, the extracellular levels of adenosine increase massively, reaching micromolar range [51,52]. In these pathological contexts, adenosine accumulation stems from increased extracellular depho
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Tension within the network could be explained by two
2024-04-24
Tension within the network could be explained by two potential mechanisms: the more classical contractility that is dependent on motor proteins that are pulling PNU-120596 filaments towards each other [10]; or contractility that is caused by disassembly of a crosslinked network of actin filaments [
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br Materials and methods br Results br
2024-04-24
Materials and methods Results Discussion Very few ARF inhibitors have been developed to study the key functions these small GTP-binding proteins play in pathophysiology. The natural compound Brefeldin A (BFA) has exhibited drastic effects in cells such as collapse of the Golgi because of it
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br Results and discussion The morphology and structure of ac
2024-04-24
Results and discussion The morphology and structure of cathepsin g samples were observed using an SEM, as shown in Fig. 1. The length and thickness of the actin filaments were regulated with ABPs to mimic the various actins observed in cells. We prepared three types of F-actin with or without ge
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Introduction Microdialysis is an in vivo
2024-04-24
Introduction Microdialysis is an in vivo-technique which allows continuous sampling of small molecular weight substances (such as neurotransmitters, metabolites and neuropeptides) from the extracellular space of different tissues or organs, e.g. brain, muscle or skin. While the implantation of the
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Although CP has been an important
2024-04-23
Although CP has been an important research subject in the field of antigen processing and presentation, the mechanisms of presentation of intracellular PF 04418948 by MHC II received considerably less attention. Interestingly, pioneering work by the Münz laboratory has pointed to an involvement of
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There are however concerns of potential
2024-04-23
There are however, concerns of potential side-effects that should also be taken into account. Even though some studies pointed towards a potentially greater radiosensitising effect in p53-deficient tumours, ATM inhibition radiosensitises Ivachtin in general, which raises the concern of normal tissue
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