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Overall the DDR kinase domain has a typical kinase domain
2019-11-05
Overall, the DDR1 kinase domain has a typical kinase domain structure and adequate sequence and/or structure similarity with other kinase domains, as shown in Fig. 2, which allow homology modeling of the active and inactive conformations. In addition to conformational changes to the activation loop
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The identification of a functional leucine rich
2019-11-05
The identification of a functional leucine-rich NES mediating 8E7 nuclear export led us to analyze the interaction between 8E7 and CRM1 nuclear export receptor. HeLa cell lysates containing EGFP-8E7, EGFP–8cE7, EGFP-16E7–NES (as a positive control), or EGFP (as a negative control) were incubated wit
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DGK negatively regulated the extension of long axon
2019-11-05
DGKδ negatively regulated the extension of long axon/neurite (Fig. 4, Fig. 5, Fig. 6). The results strongly suggest that deficiency of DGKδ induces OCD-like behavior by enhancing axon/neurite outgrowth. DGKδ positively regulates growth factor signaling (Crotty et al., 2006). Therefore, DGKδ deficien
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Compound was generated using a literature procedure and requ
2019-11-04
Compound was generated using a literature procedure and required two-step Dess–Martin-periodinane/Pinnick oxidation prior to the methylation of the sulfonamide. Compound () was obtained from the Suzuki coupling of the methyl ester intermediate (en route to Rhodamine 123 chloride ). Hydrolysis of
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Angiomatoid fibrous histiocytoma originally described as ang
2019-11-04
Angiomatoid fibrous histiocytoma (originally described as angiomatoid malignant fibrous histiocytoma) is a soft tissue tumor of intermediate biologic potential. AFH typically arises within extremity deep dermis and subcutis in children and young adults,157, 158, 159 but can arise in older adults and
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Ramos cell http www apexbt com
2019-11-04
Ramos cells carry a non-functional p53 and constitutively express the transcription factor, NF-κB (Nazari et al., 2011, Zand et al., 2008). There is much evidence to support the conclusion that the interruption of NF-κB activation promotes apoptosis in several hematological malignancies (Fabre et al
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The effect of ET activity on
2019-11-04
The effect of ET-1 activity on the development of experimental pulmonary fibrosis has also been examined by other investigators. One study found that repeated administration of Bosentan, an ERA used to treat pulmonary arterial hypertension (PAH), significantly decreased bleomycin-induced pulmonary f
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ApoE is secreted from astrocytes glia into the interstitial
2019-11-04
ApoE is secreted from astrocytes/glia into the interstitial fluid and is important for metabolizing Aβ because of its propensity for binding Aβ as a cholesterol and phospholipid acceptor in reverse cholesterol transport [8]. Aβ oligomers show a direct toxicity to neurons, and ApoE inhibits oligomer
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In addition to tissue resident stromal and myeloid
2019-11-04
In addition to tissue-resident stromal and myeloid cell populations, ILCs also readily engage in positive-feedback loops with myeloid phospholipase inhibitor recruited from the circulation. TNF-α produced by inflammatory monocytes recruited to the lungs of mice infected with Klebsiella pneumoniae ma
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In normal cells the apoptotic stimuli lower the
2019-11-04
In normal cells, the apoptotic stimuli lower the expression level of antiapoptotic proteins by increasing turnover rate and preventing the constant degradation of proapoptotic proteins. Thus, the dysregulation of anti-/pro-apoptotic proteins will confer the survival of cancer cevimeline mg via enha
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In studies directed toward the development
2019-11-04
In studies directed toward the development of sequence-specific major-groove binding small faah inhibitor [11], we desired a non-intercalating molecular scaffold that could direct attached moieties into the major groove. As an initial step toward this goal, we wished to study the DNA binding mode
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In Senegal malaria remains a formidable public health issue
2019-11-04
In Senegal, malaria remains a formidable public health issue, causing significant morbidity and mortality in infants and pregnant women (WHO Malaria Report, 2012). In the absence of an effective vaccine, the National Malaria Control Program has followed WHO recommendations for IPTp-SP since 2003. Th
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br Introduction Sphingolipids are ubiquitous membrane compon
2019-11-04
Introduction Sphingolipids are ubiquitous membrane components of all eukaryotic cells belonging to a group of complex lipids. The basic structure of sphingolipids is composed of a sphingoid long chain base (LCB) linked to a fatty AZD 2281 via an amide bond to form a ceramide [1]. In animals, sphi
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The following are the supplementary
2019-11-04
The following are the supplementary data related to this article. Acknowledgments Introduction Cyclooxygenases metabolize arachidonic epz to five primary prostanoids, PGE2, PGF2, PGI2, TXA2 (TX), and PGD2. These lipid mediators interact with specific members of a family of distinct G-protein
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br Activatable photoacoustic probes Photoacoustic PA imaging
2019-11-04
Activatable photoacoustic probes Photoacoustic (PA) imaging is a recently developed technique [47]. The imaging approach uses probes that absorb a pulsed laser beam and convert light energy into acoustic signals. It combines the advantages of the high sensitivity offered by optical imaging and th
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