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Nociceptive and hyperalgesic actions of ET are produced thro
2020-02-04
Nociceptive and hyperalgesic actions of ET-1 are produced through ETA and ETB receptors. Previous reports indicate that ETA receptor antagonists in peripheral tissues are effective in inhibiting ET-1 induced hyperalgesia, and attenuation of neuropathic pain in rats [16]. Studies have also shown that
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br Conflict of interest statement br Introduction Endothelin
2020-02-04
Conflict of interest statement Introduction Endothelins (ETs) are a family of multifunctional, naturally occurring peptides with long-lasting vasoconstrictor and pressor effects (Zhou et al., 2004). They are synthesized as a large protein, the pre-proET-1 or Big ET-1, which is subsequently cle
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br DGKs bind and regulate other
2020-02-04
DGKs bind and regulate other signalling proteins Based on the evidence noted above, DGKs achieve specificity of function through a combination of post-translational modifications, the availability of cofactors, and through the availability and access to substrate DAG. DGKs appear to achieve an a
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The use of SP in IPTp may
2020-02-04
The use of SP in IPTp may not be the only driver of parasite polymorphisms in this population, because Senegal has used sulfadoxine and/or pyrimethamine in the national antimalarial treatment plan for many years, and furthermore these drugs are still being used in antibacterial combination therapy.
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Several studies suggest that the beneficial metabolic effect
2020-02-04
Several studies suggest that the beneficial metabolic effects of adiponectin in humans are primarily mediated by its HMW isoform. Increases in the ratio of HMW to total adiponectin, but not the total adiponectin level, correlated well with improved MOG (35-55) sensitivity during treatment with the
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The present study failed to demonstrate an independent assoc
2020-02-04
The present study failed to demonstrate an independent association of preoperative ChE with BCR. This is in contrast to Koie et al. who reported that pretreatment serum ChE was significantly associated with BCR in 535 patients with CaP who underwent RP (5-year BRFS rates were 77.7% and 55.0%, respec
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Previous research has suggested that the acetylcholine gated
2020-02-04
Previous research has suggested that the acetylcholine-gated chloride channels (ACCs) in Caenorhabditis elegans (Putrenko et al., 2005) exhibit the characteristics of promising drug targets. The genes that encode the various subunits of this family are present across the nematode phylum and appear t
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Exon encodes a section of the extracellular ligand binding
2020-02-04
Exon 3 encodes a section of the extracellular ligand-binding domain and two variants in the 5′ region were first identified in Drosophila melanogaster (Semenov and Pak, 1999). These variants were initially termed modules 1 and 2 and correspond to exons 3a and 3b, respectively. To date, exon 3 altern
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br Acknowledgment S A was supported by V Plan Propio
2020-02-04
Acknowledgment S.A was supported by V Plan Propio US-AccesoUSE-14793-G. Introduction Neutrophils are innate immune CX-4945 of primary importance for protecting against infections by microorganisms [1,2] through various antimicrobial abilities, including microorganism phagocytosis and antimicr
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br Materials and methods br Results
2020-02-03
Materials and methods Results Discussion PKA and Epac are two principal effector proteins involved in cAMP signaling; they are expressed in a wide range of tissues and control diverse biological functions [10]. The existence of two cAMP effectors provides more precise regulation of cAMP sig
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In conclusion we have shown that the cellular effects produc
2020-02-03
In conclusion, we have shown that the cellular effects produced by SFN in NSCLC D609 are largely mediated by SFN-induced production of ROS. Cells with higher levels of EGFR were more resistant to SFN treatment and showed resistance to SFN-induced apoptosis, suggesting that high EGFR levels protect
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Several eukaryotic E enzymes including BRE RNF
2020-02-03
Several eukaryotic E3 enzymes, including BRE1 [49], RNF8 [50], and RAD18 [24], [51], have been reported to partner with UBE2B in the ubiquitination of various targets. We examined the expression levels of these E3 enzymes in HONE1 and TW01 cells; RAD18 was highly expressed in these lamotrigine sale
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What does this mean for
2020-02-03
What does this mean for cancer therapy? We found that components of the de novo pyrimidine synthesis pathway rarely mutate in cancer, clearly showing its importance. In our experimental models, the pathway, including DHODH itself, was primed to respond when the block in CoQ redox-cycling was removed
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In this study we further investigated the involvement
2020-02-03
In this study, we further investigated the involvement of CRF1 and CRF2 receptors of the dPAG in the regulation of panic-related responses. For this, we used two animal models that associate escape behavior with panic attacks: the elevated T maze and the electrical stimulation of the dPAG (for a ful
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System Analysis and Modeling In this work a three
2020-02-03
System Analysis and Modeling - In this work, a three-level hierarchical modeling – composed by combinatorial and state-space models – is used: (1) First, failure rates () of TMS servers subsystem units are estimated through continuous Markov chains; (2) Then, the single server Ranolazine failure ra
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