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Cholesterol homeostasis is maintained through a tight regula
2020-03-18
Cholesterol homeostasis is maintained through a tight regulation between endogenous de novo synthesis, dietary absorption, utilization and excretion of bile salts. The Cl-Amidine trifluoroacetate salt receptor of cholesterol from the intestine constitutes the central part of cholesterol homeostasis
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br Mammalian DGKs current knowledge Despite our understandin
2020-03-18
Mammalian DGKs: current knowledge Despite our understanding of prokaryotic DGKs, our limited understanding of the structure of mammalian DGKs is a major gap in our knowledge. Importantly, major differences exist between prokaryotic and mammalian enzymes often revealing the fact that structural fe
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Enzyme mimics belong to a type of
2020-03-18
Enzyme mimics belong to a type of rising catalysts which show the similar function with their corresponding natural enzymes [20], [21], [22], [23], [24], [25], [26], [27], although their structures are different from natural enzymes. In the area of prodrug activation, the widely-used enzyme mimics a
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Upon Edn ligand binding endothelin receptors can induce a va
2020-03-18
Upon Edn ligand binding, endothelin receptors can induce a variety of intracellular signaling cascades leading to diverse cellular responses such as contraction in the case of smooth muscle cells, or cell growth and mitogenesis. Ednrs are expressed in a variety of cell types and tissues, for example
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The different serotypes A G
2020-03-18
The different serotypes (A-G) have unique receptors to which they bind to produce the toxic effect on the nerve cells. (Lance, 2004, Rosetto et al., 2014). Intracellularly, the endopeptidase activity of different serotypes of BoNT target selectively a unique group of proteins, the SNARE Illumina 384
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It is interesting to note
2020-03-18
It is interesting to note that BCA Protein Quantitation Kit our results show a very similar behavior in binding of DDR2 ECD to immobilized a-telo (bovine-dermal) versus telo- (rat-tail) collagen I as a function of its oligomeric state. Thus, the telopeptide region of tropocollagen exerts little inf
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A major finding to emerge
2020-03-18
A major finding to emerge from this study is a conserved regulatory scheme deployed by both innate and adaptive lymphocytes, which is coordinated by a cohort of TFs. The scheme functionally compartmentalizes effector Cinobufagin that circulate between blood and peripheral tissues from self-renewing
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In general cellular senescence is considered a programmed
2020-03-18
In general, cellular senescence is considered a programmed response to stress that can be activated by oxidative stress, irradiation or action of substances or drugs. These stressors cause DNA damage and, through the action of specific proteins (p53 and p21), lead to cell senescence (di Fagagna, 200
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In addition to glutamatergic inputs the RTn
2020-03-18
In addition to glutamatergic inputs, the RTn integrates cholinergic, serotonergic and noradrenergic synapses of fibers coming from nuclei located in the brainstem (Asanuma, 1992, Morrison and Foote, 1986, Pare et al., 1988) involved in the alternating firing mode and in the frequency changes of reti
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The present study provides the first evidence
2020-03-18
The present study provides the first evidence that the human uroepithelial amg 232 in vitro respond directly, within 48h, to this carcinogen by promoting extensive vacuolation and DAPK expression. By using the TEM, ICC and Western blotting, we found that the arsenite-induced vacuoles were derived f
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Introduction Numerous professional governmental and
2020-03-17
Introduction Numerous professional, governmental, and media sources report a strong demand for and even a scarcity of new entrants to the fields of professional accounting and auditing. Furthermore, reports emphasize expectations of continuing high demand in the future (AICPA, 2015, Manpower Group,
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The paper is organized as follows http
2020-03-17
The paper is organized as follows. Section 2 gives a brief presentation of the JPEG-LS algorithm and respective hardware implementation. In Section 3 the fault injection model and the simulation-based susceptibility analysis method are reviewed. Section 4 provides a discussion on the susceptibility
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br Study design br Results To
2020-03-17
Study design Results To explore potential differences in the volume the different swabs absorb, the loss of weight of tubes filled with water after soaking the different swabs under defined conditions was determined. This revealed that the different swabs absorbed between approximately 0.07 an
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During the first year of
2020-03-17
During the first year of life, there was no interaction between cholesterol precursors and cholestanol, suggesting that cholesterol homeostasis was not yet developed. From the age of 1 year, cholesterol homeostasis could be considered intact. According to Fig. 1, cholesterol dgat inhibitor prevaile
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br Acknowledgments We would like to thank
2020-03-17
Acknowledgments We would like to thank the Bloomington Stock Center and the Vienna Drosophila RNAi Center for stocks used in this study. RMG was supported in part by a Professors grant to R. Losick from the HHMI and this work was supported by NSF grant 074578 to A.A.N. Introduction The catabo
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