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ATG is a key gene in autophagy
2020-07-31
ATG7 is a key gene in autophagy because it encodes E1-like activating enzyme which is required for vacuole transporting. As one of the most importance cellular mechanisms for the maintenance of a healthy cell and its homeostasis, autophagy functions as a scavenger to remove unnecessary or dysfunctio
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Previously we reported the structure
2020-07-31
Previously, we reported the structure–activity-relationships (SAR) of a series of pyrazinone-based CRF receptor antagonists, , , leading to highly potent and efficacious compounds such as , and ultimately to the discovery of (BMS-764459, ). Detailed SAR studies of the lower phenyl/pyridyl substituen
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Coactivator binding induces substantial APC C conformational
2020-07-31
Coactivator binding induces substantial APC/C conformational changes that globally shift the platform and catalytic core into proximity of the substrate-binding module and increase the mobility of domains contributing to catalysis 21, 24 (Figures 2 A and 4 B). Most strikingly, repositioning of APC4
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Mutation of RING type E s
2020-07-31
Mutation of RING-type E3s, or modulation of their activity in other ways, is often associated with human disease. BRCA1, an E3 that plays critical roles in DNA repair, is mutated in familial breast and ovarian cancers [2]. Mutations in components of the FANC ubiquitin ligase, also involved in DNA re
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br Functional significance Defects of the lysyl
2020-07-31
Functional significance Defects of the lysyl hydroxylases LH1, LH2, and LH3 impair collagen secretion and stability in the extracellular matrix, and cause rare connective tissue disorders such as Ehlers-Danlos type-VI [27], Bruck syndrome [28], and skeletal dysplasia [29], respectively. Elucidati
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br Experimental section br Introduction Protein kinases cata
2020-07-31
Experimental section Introduction Protein kinases catalyze the transfer of phosphate groups from tsa trichostatin to serine, threonine, or tyrosine residues of target proteins. This phosphorylation is an important stage in regulation of cell growth, cellular signal transduction, cell differen
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Mutation of RING type E s or
2020-07-30
Mutation of RING-type E3s, or modulation of their activity in other ways, is often associated with human disease. BRCA1, an E3 that plays critical roles in DNA repair, is mutated in familial breast and ovarian cancers [2]. Mutations in components of the FANC ubiquitin ligase, also involved in DNA re
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The binding modes of the compounds were revealed by co
2020-07-30
The binding modes of the compounds were revealed by co-crystal structures with DHODH, determined by X-ray crystallography. The compounds are found at the coenzyme Q site, as expected. -dihydroorotate (DHO), and flavin mononucleotide (FMN) are also observed in the structures which were solved at a re
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The differential expression of various cytokine receptors du
2020-07-30
The differential expression of various cytokine receptors during NK cell development implies that different cytokines are relevant for transition from one development stage to the next. Human NK 4716 develop from hematological stem cells (HSCs) in the bone marrow and complete their differentiation
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A cocktail approach can detect the activities of
2020-07-30
A cocktail approach can detect the activities of multiple CYP 450 isoforms following administration of multiple CYP-specific substrates in a single experiment. Caffeine, losartan, omeprazole, dextromethorphan and midazolam are often used as substrates in “cocktail probes” of human cytochrome CYP1A2,
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br Concluding Remarks Initially identified as a molecular
2020-07-30
Concluding Remarks Initially identified as a molecular machinery driving JWH 015 receptor through the cell cycle, it is now clear that the CDK/cyclin system fulfils many additional biological functions. CDK research is a mature field that was even covered with the Nobel Prize in 2001, but it too
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cpg was isolated in a screen
2020-07-30
cpg2 was isolated in a screen for seizure-induced genes and is regulated by physiological activity Nedivi et al. 1993, Nedivi et al. 1996. In general, screens for activity-regulated genes have isolated a number of synaptic proteins that are the components of the basic transmission machinery, indicat
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Introduction Klebsiella pneumoniae a Gram negative
2020-07-30
Introduction Klebsiella pneumoniae, a Gram-negative enteric bacterium, is an organism with significance in both biomedicine and biotechnology. Some of the strains of K. pneumoniae are opportunistic pathogens, which can cause suppurative infection, pneumoniae and urinary tract infection in humans (B
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The third pillar is Cloud Computing
2020-07-30
The third pillar is Cloud Computing. The strengths of cloud computing for users and organizations have been widely described in the literature, e.g., [33] or [44]. The benefits identified include the use of Software-as-a-Service (SaaS) and specifically Models-as-a-Service (MaaS) as on-demand high-le
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Fmoc-Tyr(tBu)-OH receptor br Materials and methods br Result
2020-07-30
Materials and methods Results Discussion Homologs of the N. crassa Ndr kinase COT-1 are important for cell differentiation and polar morphogenesis in various fungi (Buhr et al., 1996, Dürrenberger and Kronstad, 1999, Johns et al., 2006, Kodama et al., 2017, McNemar and Fonzi, 2002, Scheffer
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