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Citrus plants are of great interest because they contain lar
2020-10-26
Citrus plants are of great interest because they contain large amounts of flavonoids, and citrus fruits and their juices are consumed in large quantities around the world [18]. The flavonoid contents and profiles of citrus juices vary greatly with the type of fruit. It has been determined that citru
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Our study demonstrated that the sequential events of PKA
2020-10-26
Our study demonstrated that the sequential events of PKA and AMPK activation were involved in kinsenoside-mediated lipolysis. Within 1 h, PKA transiently inhibited AMPK activation by mitigating LKB1-mediated AMPK phosphorylation at Thr172, and PKA reduced AMPK-mediated phosphorylation at HSL-Ser565
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br Author Contributions br Funding Canadian Institutes of He
2020-10-26
Author Contributions Funding Canadian Institutes of Health Research, operating grant NMD-83126 and the internal funding from the National Research Council Canada, Charlottetown, PE, Canada. Disclosure Statement Acknowledgements Introduction Cholesterol is an essential structural comp
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The Liver X Receptor and LXRs NR H and NR
2020-10-23
The Liver X Receptor-α and -β (LXRs, NR1H3 and NR1H2, respectively) are members of the nuclear receptor superfamily that play a central role in controlling cholesterol homeostasis [9], [10]. In macrophages, LXRs can decrease the cellular sterol burden by inducing expression of the cholesterol efflux
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br TRIM TIF A RNF TRIM contains a RING both
2020-10-23
TRIM24 (TIF1A, RNF82) TRIM24 contains a RING-both B-boxes-coiled coil conserved structure at the N-terminus with bromo and PHD domains prior to C-terminal end (Fig. 3). This transcriptional intermediary factor is well studied in the context of transcriptional activation of nuclear receptor via ac
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p as a cyclin dependent kinase inhibitor exert
2020-10-23
p21, as a cyclin-dependent kinase inhibitor, exert significant negative regulator of proliferation, and it could be transcriptional upregulated by p53 in order to impel transient AZD1152-HQPA arrest (Romanov et al., 2010). Using western blotting, we found that the protein expression of p21 upgrades
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CAA is a carcinogenic metabolite of vinyl chloride forming
2020-10-23
CAA is a carcinogenic metabolite of vinyl chloride, forming several different DNA adducts including the cyclic Olanzapine adducts 3,N4-ethenocytosine (εC), 1,N6-ethenoadenine (εA), N2,3-ethenoguanine (εG), and 1,N2-ethenoguanine (1,N2-εG), with the A and C cyclic adducts the most predominant, and a
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Studies of LRRK tagged with green
2020-10-23
Studies of LRRK2 tagged with green fluorescent protein revealed the presence of monomeric LRRK2 in the MK-4827 Racemate of living cells, while LRRK2 oligomers were found in the proximity of the plasma membrane, suggesting that both oligomerization status and compartmentalization of LRRK2 defines it
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IL is not expressed in
2020-10-23
IL-8 is not expressed in tissues constitutively because of its strong chemoattractant, proinflammatory, and angiogenic activities. Rather, it is an inducible factor, produced by a variety of cell types, including leukocytes, fibroblasts, endothelial and epithelial cells, in response to proinflammato
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We and others have previously found that supplementation of
2020-10-23
We and others have previously found that supplementation of old rats with ALCAR remediates the age-related decay in mitochondrial bioenergetics in liver (Hagen et al., 1998a, Hagen et al., 1998b), heart (Paradies et al., 1994, Paradies et al., 1999), muscle (Pesce et al., 2010) and (+)-MK 801 Maleat
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This study was aimed to assess a number of
2020-10-23
This study was aimed to assess a number of esterase activities, namely erythrocyte AChE, plasma BuChE and BeChE, and serum PON1 towards a number of substrates, as well as the major genetic polymorphisms of BCHE and PON1in a cohort of greenhouse workers exposed to low toxicity pesticides under an int
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Pefloxacin Mesylate The significant CRF increase in the DS
2020-10-23
The significant CRF increase in the DS and the overall changes in the CRF system observed in the VM and DS during the development of sensitization suggest that this neuropeptide (and possibly urocortin) contributes to the specific molecular alterations occurring in the mesolimbic pathway that suppo
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The Ewing sarcoma breakpoint region gene EWSR
2020-10-22
The Ewing sarcoma breakpoint region 1 gene (EWSR1) is a partner in a large, diverse range of mesenchymal (and some nonmesenchymal) tumors (Tables 1 and 2). As the 5′ partner, EWSR1 is able to fuse with an array of genes. These fusions can generate genetically different but phenotypically identical n
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br Non cyclic nucleotide EPAC
2020-10-22
Non-cyclic nucleotide EPAC regulators Despite the success of 007 as a tool molecule, few studies to date have led to the identification of further EPAC-selective agonists. The most studied and controversial group of small-molecule EPAC regulators are the sulfonylurea (SU) family. SUs (Table 1) su
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Introduction Enzymes have higher selectivity specificity and
2020-10-22
Introduction Enzymes have higher selectivity, specificity and efficiency than chemical catalysts. Due to their properties and their green chemistry, biocatalysts are widely used in food, textile and pharmaceutical industry [1], [2]. A high efficient biocatalyst for industrial applications must be s
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