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Finally naringin and hesperidin have
2021-01-14
Finally, naringin and hesperidin have different glycosidic moieties (neohesperidose α-1,2 and rutinose α-1,6 respectively), bound in the same C7 position on the A ring of the flavonoid. The higher value of k/KM of RHA-Phis towards the former substrate suggests that the enzyme shows a preferential hy
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Fructose It has been reported that PGE increases expression
2021-01-14
It has been reported that PGE2 increases expression of the survivin mRNA (Baratelli et al. 2005) and promotes the stabilization of the survivin protein in some tumor Fructose (Krysan et al. 2003). However, it is unclear whether PGE2 affects the expression of survivin mRNA or promotes the stabilizat
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E ligases provide substrate recognition specificity
2021-01-13
E3 ligases provide substrate recognition specificity Ubiquitination 8220 australia and substrate specificity in mammals is achieved by the existence of over six-hundred E3-ubiquitin ligases that catalyze the final step of ubiquitination, compared with only one E1 and very few E2 enzymes known till
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br Materials and methods br Results
2021-01-13
Materials and methods Results Discussion We recently detected phosphorylation of tyrosine Y102 in BPV-1 E2 and reported that FGFR3 binds to E2 and limits E1 dependent viral DNA replication (Culleton et al., 2017, Xie et al., 2017). In the current study, we addressed the potential role of ot
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The following is the supplementary data
2021-01-13
The following is the supplementary data related to this article. Introduction Diacylglycerol kinase (DGK) phosphorylates diacylglycerol (DG) to produce phosphatidic Cepharanthine (PA) (Baldanzi, 2014, Goto et al., 2006, Merida et al., 2008, Sakane et al., 2007, Topham and Epand, 2009). To date,
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br Discussion Electroporation is a convenient and efficient
2021-01-13
Discussion Electroporation is a convenient and efficient way to introduce foreign material into IL-18, human recombinant protein [10], [16], [17], [18]. There are a lot of different protocols for transfection with electroporation. It was reported that there are several parameters that are relevan
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Traditionally serum triglycerides have been measured in the
2021-01-13
Traditionally, serum triglycerides have been measured in the clinic in the fasted state in order to reduce variability and also to facilitate the calculation of LDL-cholesterol via the Friedewald equation, which was derived using fasted samples (Warnick and Nakajima, 2008). We have previously report
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Our finding that activating DDR variants are a cause of
2021-01-13
Our finding that activating DDR2 variants are a cause of this disease suggested that the ABL inhibitor dasatinib, a leukemia drug that also inhibits DDR2, could be used for treatment of affected individuals.10, 11 To examine the effect of dasatinib on p.Leu610Pro- and p.Tyr740Cys-induced autophospho
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Pathological changes in animal are
2021-01-13
Pathological changes in animal are powerful indicators of the exposure to environmental stressors. The liver serves as an appropriate organ for the study of pollutant effects because of its high capacity to accumulate pollutant and its susceptibility to histopathological damage by pollutants (Padmin
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It has previously been shown that human
2021-01-13
It has previously been shown that human melanocytes are responsive to a multiplicity of hormonal triggers [10], particularly to pituitary or ovarian hormones [11]. Studies concerning the effects of Helioxanthin derivative 5-4-2 mg on human melanocytes led to inconsistent data [12], [13]. Im et al.
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The inhibition of FAS by C
2021-01-13
The inhibition of FAS by C75 produces an accumulation of malonyl-CoA which is difficult to reconcile with the activation of CPT1 reported by others [2], [16], [17], [18]. To unravel this paradox the mechanism of action of C75 needs to be examined. We recently demonstrated that C75 is converted in vi
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The best preserved individuals were selected for isotope ana
2021-01-13
The best preserved individuals were selected for isotope analysis of diet (Table 2). These represent 21 individuals including four subadults: two young children aged between 1.5 and 2.5 years old, one child between 7 and 11 years old and one adolescent (12–16 years old), and 17 adults including six
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br Results and discussion br Conclusion This study describes
2021-01-13
Results and discussion Conclusion This study describes the development of a highly sensitive on-sorbent derivatisation technique, using the novel high-surface area CMV devices, to sample methamphetamine vapour. Previous methods for air sampling for methamphetamine such as sampling cassettes ha
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SPR was used to measure biomolecular kinetic interactions
2021-01-13
SPR was used to measure biomolecular kinetic interactions between TERRA G-quadruplex and ligand in the present study. SPR is a widely used method, but cannot tell which specific type of interaction happened. Compounds with similar structures probably have similar mechanism of interaction, while comp
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A putative SHBG receptor SHBG R has
2021-01-13
A putative SHBG AI-10-49 mg (SHBG-R) has been postulated for about thirty years [66], [69], [70]. The characterization of this receptor has been researched by several groups. There are different ideas on how this receptor works. On the one hand Fortunati et al. provide evidence that SHBG is already
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