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Erlotinib Two photon microscopy experiments demonstrated tha
2021-03-25
Two-photon microscopy experiments demonstrated that most contacts between GC B and Tfh cells are of short duration (about 2 min), and only about 4% of these contacts lead to the formation of stable conjugates (5 to 60 min) (Allen et al., 2007). Similarly, during extrinsic peptide stimulation, some r
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Autophagy is a degradation pathway
2021-03-25
Autophagy is a degradation pathway existing in all eukaryotic organisms. It is the main system for the degradation of bulk cytoplasmic components in cells (Feng et al., 2014), but it also plays a crucial role in other processes, as immunity (Wileman, 2013), mitochondrial (Dengjel and Abeliovich, 201
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br DNA PK After sensing
2021-03-25
DNA-PK After sensing and binding to the DSB, Ku quickly recruits DNA-PKcs to the site of the DNA break. Similar to Ku70/80, recruitment of DNA-PKcs to DSBs occurs within seconds of their creation [12]. The interaction between Ku70/80 and DNA-PKcs requires the presence of dsDNA and the complex for
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Does a universal mechanism for TLS exist Our previous studie
2021-03-25
Does a universal mechanism for TLS exist? Our previous studies using the bacteriophage T4 DNA polymerase generated the model provided in Fig. 7 that quantifies the molecular forces influencing key steps in the polymerization pathway during the replication of a non-instructional versus miscoding DNA
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In our current work we
2021-03-25
In our current work, we have undertaken liquid phase combinatorial synthesis methods for the synthesis of 1,2,5-trisubstituted benzimidazole derivatives as hDHODH inhibitors. Synthesised Vinpocetine were also screened by molecular docking studies over the reported hDHODH structure. The synthesised
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Our current understanding of nucleotide metabolism
2021-03-25
Our current understanding of nucleotide metabolism in has made it possible to identify numerous proteins which serve essential roles in the life cycle of the parasite. One such protein is thymidylate synthase-dihydrofolate reductase (TS-DHFR), a bifunctional enzyme which is necessary for the produc
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DAPK is a kD Ca calmodulin CaM regulated Ser
2021-03-25
DAPK is a 160-kD Ca2+/calmodulin (CaM)-regulated Ser/Thr kinase that mediates cell death. The activated forms of DAPK and DRP-1 are capable of inducing two distinct cytoplasmic events characteristic of programmed cell death, including membrane blebbing and the formation of autophagic vesicles (Inbal
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Moreover a ligand for fusin has
2021-03-25
Moreover, a ligand for fusin has recently been found: the lymphocyte chemoattractant stromal-derived factor-1 (SDF-1) binds to CHO SF1670 transfected with fusin and promotes secondary messenger production (Bleul et al., 1996; Oberlin et al., 1996). A new name, CXCR-4, has been proposed for the rece
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cb 839 Treatment related adverse events have been
2021-03-25
Treatment-related adverse events have been a serious issue in clinical application. Severe toxicity has been reported in clinical trials using antibody blockade of CSF-1R (20 mg/kg), PD-1, and CTLA-4.29, 30, 31 However, apparent side effects were not observed in our study with PLX3397 treatment alon
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We thank Dr Hongqiang Qin at Dalian Institute of
2021-03-25
We thank Dr. Hongqiang Qin at Dalian Institute of Chemical Physics, Chinese Academy of Sciences for technical assistance in mass-spectrometric analysis. We thank Prof. Quentin Liu at Dalian Medical University and Prof. Qiang Shen at M.D. Anderson Cancer Center for helpful discussion and comments. Dr
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The present study showed evidence that the
2021-03-24
The present study showed evidence that the AT1 and the ETA receptors were not expressed near or on the plasma membrane as monomers, but also as possibly constitutive dimers and tetramers. For both receptors, the proportion of monomers, dimers and tetramers were unaffected by their respective agonist
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In the previous study glutamyl endopeptidase of B
2021-03-24
In the previous study glutamyl endopeptidase of B. intermedius has been reported to be distributed in the OU749 of B. intermedius as follows: 90% of synthesized enzyme has been detected in the culture liquid, 9.3% of glutamyl endopeptidase—in the fraction of membrane proteins [20]. The distribution
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Previous studies in the Swiss Webster mouse Rosengren
2021-03-24
Previous studies in the Swiss Webster mouse (Rosengren et al., 1995) and the Sprague–Dawley rat (El Sisi et al., 1993) have shown that retinol pretreatment potentiates the hepatotoxicity of paracetamol. The current study is designed to investigate further this interaction in mice. To accomplish this
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br Discussion Nowadays data of uncommon EGFR mutations are
2021-03-24
Discussion Nowadays, data of uncommon EGFR mutations are limited, considering that patients carrying these rare alterations are usually excluded from clinical trials. Available survival data of activity of EGFR TKIs on this class of mutations, coming from a small number of usually retrospective s
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Proof of concept studies with
2021-03-24
Proof-of-concept studies with disulfiram suggest the potential utility of DβH inhibitors for treatment of cocaine use disorder. In a study of 74 subjects stabilized on methadone and randomized into disulfiram and placebo groups for 10weeks, disulfiram treatment reduced cocaine-positive urines, and d
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