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We further evaluated the functional relation between
2021-07-05
We further evaluated the functional relation between promoter regulation of the tumor suppressor genes and in fresh frozen, microdissected tumor tissue from 55 patient with clear cell renal carcinoma. In addition, normal-appearing tissue from the same patient taken distal of the tumor and later hi
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Since free testosterone diffuses into a target organ
2021-07-05
Since free testosterone diffuses into a target organ [1], a remarkable increase in free testosterone in plasma is expected to enhance androgen response in target organs including the prostate. In fact, the results of the present study showed testosterone and DHT levels, and mRNA expression levels of
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As the principal receptors for regulating
2021-07-05
As the principal receptors for regulating the inflammatory process in mammals, CXCR1 and CXCR2 have an important role in regulating the trafficking of phagocytes such as neutrophils, monocytes and macrophages (Viola and Luster, 2008). The evidence gathered to date from fish studies are in agreement
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Flexible alignment of isopropylphenylaminobenzimidazole with
2021-07-05
Flexible alignment of 7-isopropylphenylaminobenzimidazole 16 with the lead Sorafenib 1 was performed using MOE. It was found that the aryl group of compound 16, exemplified as a yellow circle in Figure 2, overlapped well with the corresponding alkyl chain of compound 1 as well as the other key func
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The pure component paramet http www apexbt com
2021-07-05
The pure component parameters were taken from literatures. The 4C association scheme was considered for all the H2O, MDEA and H2S. Furthermore, CO2 supposed to be a non-associating component which can construct a cross-association with H2O through acceptations of an AMD-070 pair. Some of the possibl
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The best preserved individuals were selected for isotope ana
2021-07-05
The best preserved individuals were selected for isotope analysis of diet (Table 2). These represent 21 individuals including four subadults: two young children aged between 1.5 and 2.5 years old, one child between 7 and 11 years old and one adolescent (12–16 years old), and 17 adults including six
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This study has several limitations First
2021-07-05
This study has several limitations. First, despite the relatively large number of participants for a pharmacological neuroimaging study, sample sizes for examining the modulation of THC effects by COMT GSK 2837808A were small. Therefore, these particular findings should be interpreted with caution a
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br Collagens as new drivers
2021-07-05
Collagens as new drivers of zebrafish tissue regeneration Contrary to mammals, zebrafish possess very high regeneration capacities and thereby represent a versatile model to study tissue and organ regeneration. Adult fish can fully reconstruct their brain, spinal cord, retina, kidney, liver, panc
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br Introduction Estrogens play an important role in
2021-07-05
Introduction Estrogens play an important role in the mini prep mg (Arevalo et al., 2015). During several decades, estrogen withdrawal in women has been associated with cognitive impairment, increased Alzheimer's disease (AD) risk (Pike, 2017) and with psychiatric disorders such as schizophrenia
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br Conflicts of interest br Author contributions
2021-07-05
Conflicts of interest Author contributions Acknowledgements This work was supported by the University of Brescia (ex 60%) and Siderurgica Leonessa research funds to AF. RR was supported by Associazione Italiana per la Ricerca sul Cancro - AIRC (MFAG 18459 grant). We are grateful to Umberto
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In the present study promoting bile acid synthesis by
2021-07-05
In the present study, promoting bile KH CB19 synthesis by activating EP4 receptors was shown to exert protection against hepatic steatosis. This finding may be relevant for treatment of non-alcoholic fatty liver disease, a major cause of liver disease and prominent indication for liver transplantati
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Several effective strategies have been developed to
2021-07-05
Several effective strategies have been developed to design activatable MR probes according to the Solomon, Bloembergen and Morgan (SBM) theory, including modulation of the number of inner-sphere water molecules (q), the rotational tumbling time (τ) and the residence lifetime of inner-sphere water mo
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Using the juxtarenal PPE the induction of juxta and supraren
2021-07-05
Using the juxtarenal PPE, the induction of juxta- and suprarenal aneurysms is described herein (Fig. 3A). The infra-/suprarenal part of the Fmoc-Phe-OH can now be investigated separately, taking into account different embryological backgrounds and varying reactivity to differing stimuli (reviewed b
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In order to further understand the biological
2021-07-05
In order to further understand the biological significance of cell-collagen X interactions, we have examined the possibilities of involvement of other collagen receptors in cell binding to collagen X. The present study demonstrates that collagen X is a ligand for DDR2. DDR2 has been observed to bind
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During the host response to inflammation inflammatory
2021-07-05
During the host response to inflammation, inflammatory mediators, including release of pro-inflammatory cytokines, have been associated with altered content, expression, and activity of CYP450 enzymes, consequently leading to alterations in the metabolism and elimination of certain drugs. The losses
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