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The presented results speak for the direct effects of ghreli
2021-12-02
The presented results speak for the direct effects of ghrelin on rat spermatozoa, which are accomplished by the activation of the GHSR-1a receptor. Thus, the results seem to be of physiological significance in vivo since ghrelin, the natural ligand of GHSR-1a, was found to be present in the seminal
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Another TKI used in cancer therapy
2021-12-02
Another TKI used in cancer therapy is the Abl inhibitor imatinib mesilate which has also a beneficial effect on glucose homeostasis in diabetic humans [39], [40], [41]. Imatinib has a clear impact on NFκB activation and anti-apoptotic preconditioning of β-cells [39], attenuating islet inflammation [
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br Redox cancer therapy The understandin
2021-12-02
Redox cancer therapy The understanding of ROS mechanisms supported the development of two parallel anticancer strategies based on ROS modulation, the use of antioxidants for cancer prevention and the use of ROS inducers to exacerbate oxidative stress to lead cancer Mevastatin to death [27], [133
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Mammals and birds are sensitive either to hypo
2021-12-02
Mammals and birds are sensitive either to hypo or hyper glycemia. In contrary some frogs when freezing/thawing experience very high glycemia (Storey and Storey, 1986). Nevertheless when the effect of temperature on Fru-2,6P2 concentration was investigated, the constant glucose level in frogs kept at
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Another property shared between Hat p
2021-12-02
Another property shared between Hat1p and Rtt109p is a transient or substoichiometric interaction with Asf1p. Asf1p is necessary for the acetylation of histone H3 lysine 56 by Rtt109p. However, they do not appear to form a stable complex [22], [24], [27], [84], [90]. Surprisingly, the original type
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Importantly HDACi mediated effects are cell and HDAC specifi
2021-12-02
Importantly, HDACi-mediated effects are cell and HDAC specific; different effects and outcomes have been observed in different cell types, targeting different HDAC isoforms. While HDACi exhibit a strong proapoptotic potential in human leukemia AZD8186 19, 20, 21, 22, they have a limited ability to
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GSK is inhibited by serine phosphorylation at a residue its
2021-12-02
GSK-3 is inhibited by serine DAPI hydrochloride at a residue its N-terminus (Ser 9 in GSK-3β and Ser 21 in GSK-3α) [52], [53], [54]. This raised the possibility that the N-terminal tail may function as a pseudo-substrate by mimicking the pre-phosphorylated substrate. The interaction mode of the pse
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Additionally OsGly I overexpressing transgenic rice
2021-12-02
Additionally, OsGly I-overexpressing transgenic rice plants had higher grain yields than WT (Table 2). Although there were no significant differences in the number of effective panicles per plant, panicle length, grain numbers per panicle, or 1000-grain weight between WT and transgenic plants, the s
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br Materials and methods br Contributors br
2021-12-01
Materials and methods Contributors Acknowledgements This work was funded by the Ministry of Human Resources and Social Security, Shanxi Province [(2010)255], by a Shanxi Scholarship Council of China, and supported by a grant from the Alzheimer Society UK. The authors declare no conflict of
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ML133 HCl mg br Results br Discussion secretase mediated pro
2021-12-01
Results Discussion γ-secretase-mediated proteolysis of integral membrane proteins is required for diverse biological processes (Lal and Caplan, 2011). One γ-secretase target of particular interest is Notch, as recent work has shown Notch activity to be increased in obesity and associated metab
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As mentioned earlier two different
2021-12-01
As mentioned earlier two different isoforms of TFE3 [16] have been reported viz. the full length (TFE3L) and smaller (TFE3S) without exon 1&2. TFE3S lacks an N-terminal acidic activation domain which is present in TFE3L hence is a dominant negative form of TFE3L [51]. This dominant negative feature
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Chicoric acid CA is a di acylated
2021-12-01
Chicoric sb202190 (CA) is a di-acylated hydroxycinnamoyl tartaric acid ester [12] found in a variety of plant species, especially within the Astereceae family [13]. Of interest for this study, Sonchus oleraceus and Bidens pilosa plants, from Astereceae family, were used. Both S. oleraceus and B. pil
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Some studies using RNAi have recently been invalidated
2021-12-01
Some studies using RNAi have recently been invalidated by CRISPR/Cas9 [25] due to significant off-target effects of RNAi [26]. In this study, we have used both RNAi and CRISPR/Cas9 techniques and have observed consistent and similar phenotypes thus; knockdown or knockout of PATZ1 resulted in reducti
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Migration chemotaxis and trafficking of
2021-12-01
Migration, chemotaxis and trafficking of leukocytes, including eosinophils from the peripheral blood into the site of inflammation requires their adhesion to endothelial KJ Pyr 9 (Ley et al., 2007). Despite ongoing research, the histamine effect on eosinophils adhesion to endothelium cells has not
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br Prostaglandins meet Hippo The prostaglandins lie at the
2021-12-01
Prostaglandins meet Hippo The prostaglandins lie at the crossroads between inflammation, regeneration and tumorigenesis (Figure 3). Prostaglandins are synthesized from archidonic hbv by Cox1 and Cox2 enzymes [40, 41] and in the gut, prostaglandin E2 (PGE2) protects against DSS-induced colitis, bu
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