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After the successful development of molecular targeted drugs
2022-03-14
After the successful development of molecular targeted drugs in lung adenocarcinoma, substantial efforts have been made to provide similar targeted drugs in lung squamous-cell carcinoma. Because FGFR gene alteration is the most frequent occurrence in squamous-cell carcinoma, targeted therapies for F
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The fibroblast growth factor receptor FGFRs including four h
2022-03-14
The fibroblast growth factor receptor (FGFRs), including four highly conserved proteins (FGFR1-4), are important membrane sensors for extracellular signals [4]. By binding to their ligands, FGFRs are activated and can trigger various downstream intracellular signaling cascades, which is required for
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Focal adhesion kinase FAK is
2022-03-14
Focal adhesion kinase (FAK) is a non-receptor type tyrosine kinase that can further cooperatively interact with receptor tyrosine kinase signaling to regulate adhesion, migration, survival, proliferation, polarization, and differentiation [12]. Following activation, phosphorylated extracellular regu
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br Experimental procedures br Results br
2022-03-14
Experimental procedures Results Discussion This study demonstrates that the genetic disruption or pharmacological inhibition of FAAH completely prevented all manifestations of pain symptoms in an NTG-induced migraine animal model. Thus, FAAH disruption or blockade abolished the activation o
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Dysregulation of the HPA axis resulting
2022-03-14
Dysregulation of the HPA axis, resulting in alteration to both baseline and stress-induced glucocorticoid levels (e.g., cortisol and corticosterone), has been implicated in several diseases and psychopathologies, including anxiety (McEwen et al., 2015, 2016; Shin and Liberzon, 2010). For example, ba
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SID 26681509 Here we showed that microinjection of siRNA at
2022-03-14
Here we showed that microinjection of siRNA at the MII stage efficiently reduced endogenous EZH2 mRNA and protein. Although the percentage of cleaving embryos was not affected, SID 26681509 formation and blastocyst cell number were both reduced in EZH2 knockdown groups (Table 1). Similar results ha
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br Introduction The period around birth is
2022-03-14
Introduction The period around birth is a risky time for stroke in infants. Ischemic stroke has been diagnosed in about 1/4000 full-term infants (Nelson and Lynch, 2004) and perinatal stroke represents the second most frequent cause of acute seizures in this age group (Levy et al., 1985). Further
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In conclusion we have demonstrated that
2022-03-14
In conclusion, we have demonstrated that the ejection of structural zinc ions from G9a and GLP in the presence of selenium-, and sulfur-containing electrophilic small Phorbol 12,13-dibutyrate leads to inhibition of these two biomedically important epigenetic enzymes. Our work demonstrates that clin
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Evidence demonstrating the interplay between hypoxia and
2022-03-14
Evidence demonstrating the interplay between hypoxia and the dynamics of histone methylation is mounting [15], [43]. For example, hypoxia leads to an increase in H3K4me3 by inhibiting their responsible demethylase [44]. Hypoxia also leads to an increase in H3K9me2 by upregulating the methyltransfera
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br Conclusions In summary our results
2022-03-14
Conclusions In summary, our results demonstrate that in short term effect, TBT induced concentration-dependent vasorelaxation of HUA rings. Regarding the long term effects, exposure to a concentration of 100 μM TBT the human umbilical corticotropin-releasing factor have a dual effect, and a decre
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br New design of an HIF injector Since
2022-03-14
New design of an HIF injector Since the invention of RFQ, RFQ-based 1 GW HIF plans have been proposed in Japan, Europe and the Soviet Union, such as HIBALL, HIDIF and HIBLIC. In these plans, driver linacs were numerous, huge and complicated. Considering the space-charge-effect of the intense heav
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Furosemide sale br Conclusion br Author contributions br
2022-03-14
Conclusion Author contributions Acknowledgements We thank Furosemide sale USC Center for Craniofacial Molecular Biology (CCMB) for their extensive guidance and teaching in biochemical techniques. We acknowledge Laurel Fisher, PhD for her contribution to statistical analysis of the data. We
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br Results and discussion br Conclusions In summary we gener
2022-03-12
Results and discussion Conclusions In summary, we generated analogues of the hit compounds 1–3, studied their structure–activity relationships, and created a series of highly potent GPR55 agonists. The most potent agonists among the series were 17a-b, 17e, 17g and 17l with EC50 values below 10
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Rapid action of E on GnRH neurons has been
2022-03-12
Rapid action of E2 on GnRH neurons has been known for some time. E2 hyperpolarizes guinea pig GnRH neurons, alters cAMP production in GT1-cells and stimulates or inhibits [Ca2+]i oscillations within 15 min (Lagrange et al., 1995; Navarro et al., 2003; Temple et al., 2004; Romanò et al., 2008). Impor
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On the other hand we have previously demonstrated that
2022-03-12
On the other hand, we have previously demonstrated that gelsemine displaced the H3-strychnine from membrane fractions of rat spinal cord homogenates. In addition, spinal gelsemine antinociception was blocked by intrathecal injection of the specific glycine receptor antagonist strychnine or gene sile
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