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br Conclusions In summary the present results showed
2024-07-20
Conclusions In summary, the present results showed that ageing diminished arginase activity only in clearance tissues and that l-arginine supplementation did not induce major changes in arginase activity thus refuting a role of arginase in the potential deleterious effects of l-arginine supplemen
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br Materials and methods br Results br Discussion Fluoride
2024-07-20
Materials and methods Results Discussion Fluoride can readily penetrate cellular membranes and seriously damage the structure and physiological function of cells (Zhou et al., 2015). Several studies have shown that excessive fluoride can decrease the viability of cells and that the growth o
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Plant defensins are cysteine rich cationic
2024-07-20
Plant defensins are cysteine-rich cationic peptides of 5–8 kDa whose mature domain comprises 45 to 54 amino AH 7614 residues, with an isoelectric point around 9. The global fold of plant defensins consists of a cysteine-stabilized motif (CSα/β) made up of an α-helix and a triple-stranded β-sheet st
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br Nanoparticle Conjugated Topoisomerase Inhibitors The safe
2024-07-20
Nanoparticle-Conjugated Topoisomerase Inhibitors The safety and efficacy of topotecan administered as LDM or MTD have been evaluated in several preclinical studies and a few clinical trials whose results showed that there can be significant adverse effects likely precluding its use in patients [5
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It is noteworthy that in both
2024-07-20
It is noteworthy that in both cases there is a higher risk for prematurity [44], [61], [97], [98] and for deliveries of newborn small for GA [89], [95], [97], [98]. sFlt-1:PlGF has been showed to be inversely correlated with GA at birth, since 86% of pregnant women who gave birth at It is also obse
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Salvia the largest genus in the
2024-07-19
Salvia, the largest genus in the family Lamiaceae, comprises over 900 species that are distributed globally [14], [15], [16]. The genus Salvia has been assessed in many studies because it is a rich source of polyphenol compounds, of which more than 160 have been isolated from plants in the genus, so
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In silico docking analysis performed in the
2024-07-19
In silico docking analysis performed in the current study indicated that TCDD strongly binds to AhR-LBD. Moreover, the formation of the TCDD/AhR-LBD complex was confirmed experimentally with the use of EMSA. We found that 10nM TCDD after 2 hours of incubation not only bound to the AhR in the porcine
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br Conflict of Interest br Transparency Document br Introduc
2024-07-19
Conflict of Interest Transparency Document Introduction Mitoxantrone (MXT) is an androstenedione chemotherapeutic agent that is used to treat acute nonlymphocytic leukemia, acute lymphoblastic leukemia, prostate cancer, metastatic breast cancer, and non-Hodgkin’s lymphoma [13], [14]. It is
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Since the introduction of zebrafish into the laboratory many
2024-07-19
Since the introduction of zebrafish into the laboratory, many milestones have been achieved that firmly establish this organism as a prominent genetic model for biology and medicine. Many features make this species an organism of easy maintenance in laboratory which provides advantages to understand
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The geometry of two three four and five acetylcholine neutra
2024-07-19
The geometry of two, three, four and five citco neutral radical ACh molecule complexes with various electronic configurations, i.e. with various multiplicities equal to 1, 2 and 4 (for ACh trimer) were determined using DFT with the unrestricted B97d/SVP potential/basis set in Gaussian09 program pack
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In the present study the alternative splicing of
2024-07-19
In the present study, the alternative splicing of several nAChR subunits was identified in the oriental migratory locust (Locusta migratoria manilensis Meyen), a serious worldwide pest to agricultural production and also a model insect species [5]. Several α subunits were tried to co-express with ra
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CYP A is one of the key
2024-07-19
CYP3A4 is one of the key metabolizing Quercetin of the cytochrome P450 (CYP) superfamily of heme-containing monooxygenases. As the CYP family of enzymes plays important roles not only in the xenobiotic metabolism and detoxification of a large number of drugs, but also in the biosynthesis of endogeno
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A contribution of V ATPase subunits specifically
2024-07-19
A contribution of V-ATPase subunits specifically to phagosome-lysosome fusion was uncovered by Peri and Nüsslein-Volhard who described that depletion of the VO subunit a1 in zebrafish interferes with phagosome maturation in microglial Phenyl sulfate (Peri and Nusslein-Volhard, 2008). However, loss
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The physiologic conditions and signaling mechanisms
2024-07-18
The physiologic conditions and signaling mechanisms that regulate apelin secretion and APLNR expression in malignant tissues appear to be multifactorial. Previous studies have shown that hyperplastic and neoplastic cholangiocytes secrete a variety of hormones, peptides, and growth factors that help
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PGC mediated mitochondrial biogenesis in brown
2024-07-18
PGC-1α-mediated mitochondrial biogenesis in brown fat and endothelial sennoside is in part regulated by eNOS and NO [28], [29]. Recent studies indicate that H2S not only augments NO bioavailability and signaling [11], [17], but provides protection against cardiac injury in an eNOS-dependent manner
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