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br Pannexins which form channels connecting
2022-05-09
Pannexins, which form channels connecting Tranexamic Acid with the extracellular environment, have also been studied in the setting of NASH. When open these channels participate in inflammatory processes. A decrease in lobular inflammation and oxidative stress was observed in mice with pannexin d
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Nicastrin is heavily glycosylated contributing KDa to
2022-05-09
Nicastrin is heavily glycosylated, contributing 40–70KDa to the molecular weight of human γ-secretase. Among the 16 predicted N-linked glycosylation sites in the ECD, 11 have been unambiguously identified. The glycans appear to mostly stabilize the local structure, thus contributing to the folding a
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The stability of the i
2022-05-09
The stability of the i-motif at the neutral pH has been analyzed in our previous paper [31] by tracking the rmsd changes in unbiased calculations. Fig. 7 presents, just to confirm the conclusions drawn in [12], the changes in distances between atoms forming hydrogen bonds within the i-motif structur
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Reducing the molecular weight According to a thorough analys
2022-05-09
Reducing the molecular weight: According to a thorough analysis of a large, structurally diverse Caco-2 permeability dataset using a variety of statistical techniques by AstraZeneca researchers, logD and molecular weight are suggested the most important factors in determining the permeability of dru
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The physicochemical properties of the prodrugs provided
2022-05-09
The physicochemical properties of the prodrugs provided important clues for understanding a broad range of inhibitory activities in the cell assays (Table 2). Some physicochemical properties are useful in predicting drug absorption. Considering Lipinski’s rules and the polar surface area (PSA),l-ala
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The product chain length determination mechanism of prenyltr
2022-05-09
The product chain-length determination mechanism of -prenyltransferases has not yet been elucidated, although mutational analyses of highly conserved residues and of characteristic amino secretin receptor residues in each subfamily of -prenyltransferases have enabled the understanding of the basic
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br Acknowledgments I thank Takeshi Sakaba
2022-05-09
Acknowledgments I thank Takeshi Sakaba for critical reading of the manuscript and helpful comments. This work was supported by JSPS/MEXT KAKENHI Grant Numbers 17K19466, 17H03548. Introduction The oral route of drug application is the main route in pharmacology since it is easy to handle and o
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The medicinal properties of guanidine derivatives
2022-05-09
The medicinal properties of guanidine derivatives are also of great interest due to their diverse anti-microbial, anti-inflammatory, anti-viral, and anti-cancer, activities (C and D). Guanidine-containing drugs, such as -iodobenzylguanidine and methylglyoxal bis(guanylhydrazone), were shown several
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br Conclusion Infections caused by
2022-05-09
Conclusion Infections caused by the P. aeruginosa could not be cured by current antibiotics, making multiple drug resistance of P. aeruginosa an increasing threat for human lives. Looking for a new therapeutic mechanism for infections caused by the P. aeruginosa has become a central issue. There
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br Introduction The replacement of a regular intake
2022-05-07
Introduction The replacement of a regular intake of healthy oils and fibres for a diet based substantially on high fat- and high sugar-content foods has had profound consequences for public health. These changes in the way that the populations of high income, particularly Western countries, manag
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Several studies have found that GPR possesses a distinct pha
2022-05-07
Several studies have found that GPR55 possesses a distinct pharmacology from that of CB1 and CB2, and that only certain cannabinoids act at this receptor. In transfected N6-Methyl-ATP expressing hGPR55, out of more than 20 synthetic and endogenous cannabinoids evaluated, only 2 compounds, SR141716A
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In both families GPR A mRNA in kidney fat
2022-05-07
In both families, GPR109A mRNA in kidney fat was positively correlated with NEFA as a tendency. A positive correlation between this fat depot and insulin was observed in lean-type cows. In fat-type cows, mesenteric GPR109A mRNA correlated positively with insulin and negatively with urea on a moderat
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Naringin has been shown to have significant anti
2022-05-07
Naringin has been shown to have significant anti-inflammation, anti-oxidative stress, glucolipid metabolic regulation, and myocardial protection effects (Gopinath et al., 2011, Gopinath and Sudhandiran, 2012), suggesting that it may mitigate ADC by inhibiting P2X7 receptors. In the present study, na
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Some studies show that testosterone
2022-05-07
Some studies show that testosterone may be involved in regulating cell proliferation and its stimulating effect has been proved in castrated rats (Wainwright et al., 2011), but not in mice and meadow voles (Ormerod and Galea, 2003; Benice and Raber, 2010). However, the seasonal difference in cell pr
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Post translational ubiquitination has been shown
2022-05-07
Post-translational ubiquitination has been shown to regulate a wide range of cellular responses, such as the synaptic trafficking and turnover of neurotransmitter receptors (Rape, 2018). Ubiquitination is also engaged in the modification of protein-protein interaction and intracellular signaling tra
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