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A few previous studies have examined Factor Xa inhibitors
2022-07-18
A few previous studies have examined Factor Xa inhibitors for VTE prophylaxis in hip fracture patients. In a 2001 paper, Eriksson et al. studied 1250 patients with hip fractures that had been randomized to either postoperative Factor Xa inhibitor or enoxaparin [13]. Each patient received bilateral v
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We found the FAAH CC genotype only confers risk
2022-07-18
We found the FAAH CC genotype only confers risk for anxiety if the CRFR1 minor allele combination is also present. Additionally, the FAAH AA/AC genotype was riskier than the CC if the three CRFR1 minor lipid metabolism were not present. This result is somewhat contrary to our prediction as we hypot
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Sometime ago we have described diamino
2022-07-18
Sometime ago we have described diamino-1,3,5-triazines as histamine H4R ligands,12, 13 and aryl derivatives of the 1,3,5-triazine, which attenuated inflammatory and nociceptive response in vivo in the rodent models of inflammation induced by Bedaquiline synthesis and zymosan. In this work we descri
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br Results and discussion br Conclusions
2022-07-16
Results and discussion Conclusions In summary, we generated analogues of the hit compounds 1–3, studied their structure–activity relationships, and created a series of highly potent GPR55 agonists. The most potent agonists among the series were 17a-b, 17e, 17g and 17l with EC50 values below 10
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A linker length of and atoms was found
2022-07-16
A linker length of 4 and 5 atoms was found to be optimal ( and ) compared to the only weakly active compounds with longer linkers ( and ) or the inactive compounds with shorter linker chains (–). In a next step incorporation of hetero-atoms in the linker was explored (). An amide linker as in and d
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However even if immunological tests with
2022-07-16
However, even if immunological tests with the NQ21 peptide are mostly positive [8], it doesn't mean that the structure of the NQ21 peptide is the same as that of the corresponding gp120 region characterized by a long alpha helix. Therefore, the aim of the current work was to check whether the NQ21 p
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br Conclusion br Introduction The intracellularly generated
2022-07-16
Conclusion Introduction The intracellularly generated metabolite methylglyoxal (MG, 2-oxopropanal) acts as a potent electrophile causing irreparable cellular damage if allowed to build to cytotoxic concentrations [1], [2], [3], [4], [5], [6]. The glyoxalase (Glx) system is an enzyme couple cri
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Glutamate activates cationic glutamate gated channels i e io
2022-07-16
Glutamate activates cationic glutamate-gated channels (i.e. ionotropic glutamate receptors) that mediate the fast excitatory actions of glutamate. It also activate G protein-coupled receptors, named metabotropic glutamate receptors (mGluRs) (Pin and Bettler, 2016). The eight subtypes of mGluRs are k
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To further investigate if GPR was the
2022-07-16
To further investigate if GPR40 was the functional target of these phenylpropiolic fxr agonist analogs, GW-1100, a selective antagonist of GPR40-mediated Ca2+ elevations in HEK293 cells with an IC50 value equal to 1 μM, was used to inhibit agonist-induced intracellular calcium flux [15]. HEK293-GPR
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The molecular nature of these putative Ca channels
2022-07-16
The molecular nature of these putative Ca2+ dopamine receptor antagonist is at present unknown. Apart from the NSVDC channel, which is permeable to Ca2+ [27], [15] functional Ca2+ channels have been identified in patch clamp experiments [28]. These channels, which were characterized as B-channels,
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Regulation of Gja involves a member of
2022-07-16
Regulation of Gja4 involves a member of the wingless-type MMTV integration site family, WNT4. Mice deficient in Wnt4 had reduced (30%) expression of GJA1 compared to WT mice [40]. It is thought that WNT signaling regulates GJA1 expression and GJIC in granulosa [D-Lys3]-GHRP-6 by modulating beta-cat
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Our own search towards aryl imidazole
2022-07-16
Our own search towards aryl-imidazole derived GSMs led to the discovery of the benzimidazole derivative (). It is one of the most potent GSMs to date, suffering however from sub-optimal drug-like properties. More recently, we have described the design and synthesis of bicyclic triazolo-derivatives,
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Two intermediate compounds A and B in Fig were tested
2022-07-16
Two intermediate compounds (A and B in Fig. 1) were tested for both Aβ40 and CYP3A4 inhibition activity. Potential hydrolysis of structures I and IIin vivo may produce A which is a strong CYP3A4 inhibitor. Cyclopropanol group is a suspected liability, because adrenergic antagonist B without it has a
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br Fipronil resistance associated with A S and
2022-07-16
Fipronil resistance associated with A2′S and A2′G mutations Fipronil is a second-generation NCA (Fig. 1), and A2′S and A2′G mutations provide a low level of cross-resistance to fipronil (Cole et al., 1995, Gao et al., 2007). As shown in Table 1, the A2′S AZD0156 sale confers high resistance to d
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br Results and discussion br
2022-07-16
Results and discussion Conclusion In the continued SAR study of our previous heterocycle scaffolds represented by 6015 2, we focused especially on improving their drug-like physicochemical properties directed by lipophilicity, LE and LLE. After explored several heterocyclic scaffolds, the pot
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