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Taken together our results show that at least in
2022-07-27
Taken together, our results show that, at least in the in vitro cell line model, methylation within the proximal promoter region of GHSR is an important determinant of its expression; however, to determine whether this represents a physiologically and or pathophysiologically relevant event, further
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One major issue has dominated studies of the nematode connec
2022-07-27
One major issue has dominated studies of the nematode connectome: its reproducibility. The difficulties that had to be surmounted just to assemble a complete wiring diagram precluded comparisons of the complete wiring from several different animals. Instead the earliest adult hermaphrodite wiring di
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br Material and methods br Results and
2022-07-27
Material and methods Results and discussion Discussion It is well established that the guanosine-rich DNA sequences within telomeric DNA repeats, and in the promoter regions of a number of oncogenes or proto-oncogenes such as c-myc [20,23], VEGF [28,48,49] and Bcl-2 [21,50], can readily ass
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To further investigate if GPR was the
2022-07-27
To further investigate if GPR40 was the functional target of these phenylpropiolic methoxy analogs, GW-1100, a selective antagonist of GPR40-mediated Ca2+ elevations in HEK293 cells with an IC50 value equal to 1 μM, was used to inhibit agonist-induced intracellular calcium flux [15]. HEK293-GPR40 c
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We identified three genes KEAP NAA
2022-07-27
We identified three genes—KEAP1, NAA38, and ABCC1/MRP1—as negative regulators of glutathione abundance in human cells. Like KEAP1, NAA38 appears to regulate NRF2 stability, as NAA38 deletion increased NRF2 protein levels and the expression of NRF2 target genes. NAA38 is a component of the NatC N-ter
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The current study aimed to understand the roles
2022-07-26
The current study aimed to understand the roles and the underlying mechanisms of XIST in LSCC, by focusing on the regulation by miR-124-3p, which was previously identified as a target of XIST [12]. We found that the XIST expression is positively correlated with the stages of LSCC in patients. Knockd
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br References and recommended reading Papers of particular i
2022-07-26
References and recommended reading Papers of particular interest, published within the period of review, have been highlighted as: Introduction Male sexual maturation includes gonadal maturation, secondary sexual characteristics, and the attainment of reproductive capacity [1]. Male sexual di
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br Acknowledgements br Introduction Type diabetes is a progr
2022-07-26
Acknowledgements Introduction Type 2 diabetes is a progressive metabolic disorder which is characterised by chronic hyperglycaemia due to relative insulin deficiency, insulin resistance and increased hepatic glucose production [1]. The metabolism of glucose by glycolysis increases the ATP:ADP
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QS 11 australia G protein coupled receptors GPCRs constitute
2022-07-26
G-protein coupled receptors (GPCRs) constitute a large family of 7 trans-membrane-spanning proteins that activate internal signal transduction cascades through binding to different ligands including neurotransmitters, peptides, and lipids [7]. This family of receptors has therapeutic potentials in t
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br Material and methods br Results
2022-07-26
Material and methods Results The search for proteins selectively expressed in pancreatic islet ceramidase in the Human Protein Atlas (HPA) yielded 27 hits, including well-known islet cell markers such as insulin, glucagon and pancreatic polypeptide (Table 1). The search algorithm excluded isle
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The diseases of ocular surface and the cornea are
2022-07-26
The diseases of ocular surface and the cornea are very common in ophthalmological practice and as a result there is a continuous, need for novel therapeutic options. Here, we demonstrated a corneal distribution of GPR35, a potential molecular target for new drugs (; ). The search for the expression
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To assess the roles of GPR and GPR in
2022-07-26
To assess the roles of GPR120 and GPR40 in malignant properties of pancreatic cancer cells, we generated GPR120 and GPR40 knockdown (PANC-sh120 and PANC-sh40, respectively) SB 204070 from PANC-1 (Fig. 2A). While no difference of cell growth rate between control PANC-RFP cells and PANC-sh120 cells w
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We were able to obtain several
2022-07-26
We were able to obtain several crystalline forms of CHAV Gth. The first one corresponded to the post-fusion conformation [14]. The comparison of this structure with that of VSV-Gth post-fusion conformation revealed that the PHD is the most divergent domain, with the largest differences confined to t
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br Methods and materials br Results and discussion br Conclu
2022-07-26
Methods and materials Results and discussion Conclusions This is the first study that attempted to isolate, purify and identify the characteristics of Fmoc-Ser(tBu)-OH mg from ginseng. In vitro studies have demonstrated that PGL-1 efficiently suppressed SH-SY5Y cell apoptosis induced by Aβ2
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Kern et al observed an overall improvement in behaviors
2022-07-26
Kern et al observed an overall improvement in behaviors typical for autism during TR. They used the Childhood Autism Rating Score (CARS), to determine the intensity of the change and found lower CARS values after 3 (t(21) = 2.73, p but Cy5.5 hydrazide comparison of differences in QoL improvement in
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