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br Hedgehog HH signaling plays an
2022-08-18
Hedgehog (HH) signaling plays an important role both during embryonic development and adult life. It is involved in the regulation of cell differentiation, cell proliferation and tissue polarity, as well as in the maintenance of stem cells, tissue repair, and regeneration (, ). Three ligands, Indi
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We and others have previously reported
2022-08-18
We and others have previously reported that neurons generated from iPSCs with genetic forms of AD recapitulate aspects of the disease, including increased Aβ peptide production in trisomy 21 and APP duplication neurons (Moore et al., 2015, Israel et al., 2012) and increased production of longer form
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Most of the above mechanisms are implicated in attenuation o
2022-08-18
Most of the above mechanisms are implicated in attenuation of myocardial I/R injury. However, the role of GalR2 receptor activation in cardioprotection remains unclear because of the lack of receptor subtype selectivity of peptides G2 and G3. It has been shown that Ala5-galanin (2–11) (G4) has a hi
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Having shown that some of
2022-08-18
Having shown that some of substitutions (Cl, CF) at the 2-position of the thiophene improved rat microsomal stability, and polar groups at the 4-position of the aryl ring had a beneficial effect on stability in both human and rat microsomes, we combined these features in a new set of analogs. Methyl
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The HIF complex was initially
2022-08-17
The HIF complex was initially identified as an important component of the cell machinery involved in the response and bromhexine receptor to hypoxia (Semenza, 2001). Further studies have shown that HIF can also modulate whole-body energy homeostasis by controlling hypothalamic neurons (Varela et al
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The central region of Azalanstat can be
2022-08-17
The central region of Azalanstat can be substituted with connecting alkyl chains of different nature and length. Interesting results were given by compounds with a four or five metforman mg chain, incorporating heteroatoms, such as oxygen (Fig. 2, compound 4) or sulfur, and different functional grou
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Furthermore colistin induced mitochondrial dysfunction in mo
2022-08-17
Furthermore, colistin induced mitochondrial dysfunction in mouse central nervous system and chicken neurons, axonal degeneration and demyelization of mice sciatic nerves [16,17,19]. Interestingly, mitochondrial dysfunction is a key determinant of neurodegeneration [20,21]. Also, it accumulates amino
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Interestingly in vivo infusion and
2022-08-17
Interestingly, in vivo infusion and uptake of Ang II in intact mice indicated that multiligand endocytic receptor megalin has at least some role in the uptake of Ang II and the downstream signaling process in proximal tubule Seliciclib (PTCs) in vivo [173]. Earlier in vivo studies showed that PTCs
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In contrast to sGC stimulators sGC
2022-08-17
In contrast to sGC stimulators, sGC activators promote enzymatic activity of sGC containing oxidized heme iron (Fe3+) or missing the heme group. A-350619 is one of the oldest activators of sGC to be discovered. A-350619 increased sGC activation in a non-additive manner with respect to YC-1, leading
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The amino hydroxy methyl isoxazolepropionic acid AMPA recept
2022-08-17
The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic ML347 (AMPA) receptors are related ionotropic glutamate receptors (iGluRs) that mediate fast excitatory neurotransmission, and are also typically heteromeric ion channels, composed of GluA2 subunits in conjugation with GluA1, GluA3, or GluA4 subun
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Ubiquitination of GlyRs subunit on plasma membrane has
2022-08-17
Ubiquitination of GlyRs-α1 subunit on plasma membrane has been shown to initiate the receptor dpp-iv inhibitors and subsequent degradation in lysosomes (Buttner et al., 2001). However, the specific E3 ligase responsible for GlyRs-α1 ubiquitination is largely unknown as yet. Also, the functional cons
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An increased sympathetic tone and the
2022-08-17
An increased sympathetic tone and the hormone glucagon are the main glucose mobilizing factors [28], [29]. Single-cell transcriptome analysis of human islet cells suggests the expression of Ffar1 not only in β-cells but also in α-cells [30]. Moreover, analysis of rat α-cells indicates that FFAR1 exp
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In the present study we characterized the
2022-08-17
In the present study, we characterized the expression of glucose transporters in the developing and adult mouse lens and showed that GLUT1 is the primary transporter expressed in the lens epithelium. We found that mice with a homozygous deletion of Slc2a1 from the lens epithelium developed cataracts
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br Acknowledgements We thank the
2022-08-17
Acknowledgements We thank the following individuals for notable contributions to this work: Dr. Ruth Wood, Dr. Alan Watts, Dr. Casey Donovan, Andrea Suarez, Emily Nakamoto, Allison Apfel, April Banayan, and Jonathan Cheung. This study was supported by the National Institute of Health grants, DK10
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Sperm exocytosis or acrosome reaction AR
2022-08-16
Sperm exocytosis or acrosome reaction (AR) is a regulated secretion with special characteristics essential for fertilization. The AR relies on the same highly conserved molecules that drive intracellular membrane fusion and exocytosis in all other Phos-tag Acrylamide (see [59] for a recent review).
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