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Ten strains of lactobacilli TMW isogenic with
2024-08-08
Ten strains of lactobacilli: TMW 1.1434 (isogenic with strain F19 ), TMW 1.1733 (isolated from fermented food), TMW 1.1628 (isolated from baby feces), TMW 1.1609 (isolated from baby feces), TMW 1.1734 (isolated from fermented food), TMW 1.313 (isolated from non-pasteurized Heineken beer), TMW
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Our results using RT PCR confirm earlier findings
2024-08-08
Our results using RT-PCR confirm earlier findings (Wilisch et al., 1999, Bruno et al., 2004) including the presence of both the P3A+ and P3A− isoforms of the α-subunit (Beeson et al., 1990). The lack of detection of the ε-subunit mRNAs in some thymomas, and lack of α-, β-, δ- and γ-subunit mRNAs by
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br Acknowledgments We thank the anonymous reviewers for thei
2024-08-08
Acknowledgments We thank the anonymous reviewers for their constructive comments on the manuscript, and also thank Dr. Hans-U. Dahms for his comments on the manuscript. This work was supported by a grant from the National Research Foundation (2009-0071218) funded to Young-Mi Lee. This work was al
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Whereas more research is needed to identify the precise mech
2024-08-08
Whereas more research is needed to identify the precise mechanism by which FIN exerts its antidyskinetic effect, the Pasireotide that it can negatively modulate dopaminergic transmission is also supported by our previous findings. Indeed, we have previously shown that FIN completely reversed the be
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br Mechanisms of GPCR internalization Like for other
2024-08-08
Mechanisms of GPCR internalization Like for other types of receptors, prolonged agonist stimulation often leads to GPCR internalization, which can occur via different pathways ∗[2], [20], [21], [22], [23]. Of these pathways, clathrin-mediated amikacin sulfate (CME) is the best characterized and
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Because R gene is positively regulated by T
2024-08-08
Because 5α-R2 gene is positively regulated by T and in the prostate gland (Torres et al., 2003), and our BPA-treated rats showed decreased circulating T and probably intraprostatic androgen levels, it might be responsible for the decrease of 5α-R2 expression. However, in a previous work using castra
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In addition to calpain I activity cathepsin activities have
2024-08-08
In addition to calpain I activity, cathepsin activities have been proven to be linked to apoptotic signaling. Cathepsin B and cathepsin D are two of the most abundant and well-investigated lysosome acid-dependent proteases that are involved in the apoptotic regulation (Ferri & Kroemer, 2001). Cathep
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br HMG proteins mobile modulators of chromatin structure and
2024-08-08
HMG proteins: mobile modulators of chromatin structure and cellular phenotype The term “High Mobility Group” was originally coined for the HMG proteins because of their unusual solubility properties, their small size and their rapid mobility, relative to other chromatin proteins, during gel elect
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br Conclusions br Acknowledgments The authors
2024-08-07
Conclusions Acknowledgments The authors are thankful to Hugo Santos, Olga Martinez and Ricardo Lacerda for the technical assistance provided in the maintenance of the aquaria. This work was supported by national funds, through FCT and co-funded by the European Regional Development Fund (ERDF)
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br Concluding remarks Following the disappointing outcomes o
2024-08-07
Concluding remarks Following the disappointing outcomes of Aβ immunotherapy trials for AD [62], the current prevailing concept is that disease-modifying therapy must be initiated from the presymptomatic stage of the disease because of the presumed incurability of chronic diseases once they become
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We have previously shown that the human gonadotropins hLH an
2024-08-07
We have previously shown that the human gonadotropins hLH and hCG trigger a partly irreversible stimulation of intracellular cyclic AMP accumulation in mouse Leydig Tumor ESI-09 sale (MLTC) in contrast to all other tested mammalian LHs and CG (Klett et al., 2016). In order to get a better insight i
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AdK as an important upstream regulator of adenosine based
2024-08-07
AdK as an important upstream regulator of adenosine-based homeostasis represents a promising drug target since it leads to an increase in adenosine concentrations. Taking into account that the adenosine formation is only increased in affected tissues under stress with high adenosine levels, AdK inhi
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The myasthenia scale of Millichap and Dodge was used in
2024-08-07
The myasthenia scale of Millichap and Dodge was used in our study for ease of comparison of our retrospective data with previous paediatric studies. Our results, with 30% achieving complete remission and 95% achieving at least some degree of clinical improvement following thymectomy, are comparable
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The first suggestions that the cleaved intracellular
2024-08-07
The first suggestions that the cleaved intracellular domain of APP, AICD, might transit to the nucleus and hence selectively regulate gene transcription arose from analogies with the Notch receptor signalling system where similar intra-membrane proteolysis occurs [84], [85] and it was later confirme
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Although the mechanisms of APP secretion are
2024-08-07
Although the mechanisms of APP secretion are well characterised (for review see Ref. [1]), production of soluble AChE species is less well understood although we have reported that a metalloproteinase can shed AChE similarly to APP [16], [17]. Recently it has also been demonstrated that cellular pre
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